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Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits
Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder,
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
Treatment of posttraumatic stress disorder: A state-of-the-art review
This narrative state-of-the-art review paper describes the progress in the understanding and
treatment of Posttraumatic Stress Disorder (PTSD). Over the last four decades, the scientific …
treatment of Posttraumatic Stress Disorder (PTSD). Over the last four decades, the scientific …
Neurobiology of opioid addiction: opponent process, hyperkatifeia, and negative reinforcement
Opioids are powerful drugs that usurp and overpower the reward function of endogenous
opioids and engage dramatic tolerance and withdrawal via molecular and neurocircuitry …
opioids and engage dramatic tolerance and withdrawal via molecular and neurocircuitry …
Hormonal treatments for major depressive disorder: state of the art
Major depressive disorder is a common psychiatric disorder associated with marked
suffering, morbidity, mortality, and cost. The World Health Organization projects that by 2030 …
suffering, morbidity, mortality, and cost. The World Health Organization projects that by 2030 …
Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program
We conducted genome-wide association analyses of over 250,000 participants of European
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …
Is the HPA axis as target for depression outdated, or is there a new hope?
Major depressive disorder (MDD) is a very common stress-related mental disorder that
carries a huge burden for affected patients and the society. It is associated with a high …
carries a huge burden for affected patients and the society. It is associated with a high …
[HTML][HTML] Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders
Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …
highlighting the need for improved drug treatments. In this review an overview of drugs …
Drug addiction: hyperkatifeia/negative reinforcement as a framework for medications development
Compulsive drug seeking that is associated with addiction is hypothesized to follow a
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …
The corticotropin-releasing factor family: physiology of the stress response
The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …
presence of real or perceived challenges. In this function, the brain activates adaptive …
The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions
Questions of how altered functioning of the hypothalamic pituitary adrenal (HPA) axis
contribute to the development and maintenance of posttraumatic stress disorder (PTSD) …
contribute to the development and maintenance of posttraumatic stress disorder (PTSD) …