The transcription factor p53 is an important regulator of a multitude of cellular processes. In
the presence of genotoxic stress, p53 is activated to facilitate DNA repair, cell cycle arrest …

The MDM2 protein encoded by the mouse double minute 2 (MDM2) gene is the primary
negative regulatory factor of the p53 protein. MDM2 can ligate the p53 protein via its E3 …

Abstract TP53 (p53) is the most frequently mutated gene in cancer, being altered in
approximately 50% of human malignancies. In most, if not all, cancers lacking mutation, wild …

Immune checkpoint inhibitors (ICIs), such as PD-1/PD-L1 antibodies (Abs) and anti-cytotoxic
T lymphocyte antigen 4 (CTLA-4) Abs, are effective for patients with various cancers …

Abstract Mouse double minute 2 (MDM2) is an E3 ubiquitin ligase which effectively
degrades tumor suppressor p53. In the past two decades, many MDM2 inhibitors that disrupt …

Apoptosis is a cell suicide process that is essential for development, tissue homeostasis and
human health. Impaired apoptosis is associated with a variety of human diseases, including …

Cancer arises through a complex interplay between genetic, behavioral, metabolic, and
environmental factors that combined trigger cellular changes that over time promote …

The p53 tumor suppressor plays a major role in controlling the initiation and development of
cancer by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. The MDM2 …

Venetoclax is a highly selective B-cell lymphoma-2 (BCL-2) inhibitor, which, combined with
a DNA hypomethylating agent or low dose cytarabine, results in high rates of initial …

Recently, attention has been drawn to the role of non-coding regions of the genome in
cancer pathogenesis. MicroRNAs (miRNAs) are small non-coding RNAs with 19–25 bases …