Surgery, chemotherapy, radiotherapy, and hormone therapy are the main common anti-
tumor therapeutic approaches. However, the non-specific targeting of cancer cells has made …

Nucleic acids are a promising type of therapeutic for the treatment of a wide range of
conditions, including cancer, but they also pose many delivery challenges. For efficient and …

Streptavidin and its homologs (together referred to as streptavidin) are widely used in
molecular science owing to their highly selective and stable interaction with biotin. Other …

Nearly 30 years ago, certain small, relatively nontoxic peptides were discovered to be
capable of traversing the cell membrane. These cell-penetrating peptides, as they are now …

Neurodegenerative diseases are characterized by extensive loss of function or death of
brain cells, hampering the life quality of patients. Brain-targeted drug delivery is challenging …

Arginine-rich cell-penetrating peptides (AR-CPPs) are very promising tools for the delivery of
therapeutic macromolecules such as peptides, proteins, and nucleic acids. These peptides …

Cell-penetrating peptides (CPPs) including TAT peptide (TATp) have been successfully
used for intracellular delivery of a broad variety of cargoes including various nanoparticulate …

Gene therapy has long sought to treat disease by delivering therapeutic genes to diseased
cells. However, its widespread clinical use has faltered in the face of several challenges …

Gene therapy for neurological disorders has attracted significant interest as a way to reverse
or stop various disease pathologies. Typical gene therapies involving the central and …

Mesoporous silica nanoparticles functionalized with peptides are developed for sequential
drug delivery. The RGD peptide is used for vasculature/cell membrane targeting and the …