Perspectives on the Drosophila melanogaster Model for Advances in Toxicological Science

MD Rand, JM Tennessen, TFC Mackay… - Current …, 2023 - Wiley Online Library
The use of Drosophila melanogaster for studies of toxicology has grown considerably in the
last decade. The Drosophila model has long been appreciated as a versatile and powerful …

Heavy metal exposure and metabolomics analysis: an emerging frontier in environmental health

K Ilyas, H Iqbal, MSH Akash, K Rehman… - … Science and Pollution …, 2024 - Springer
Exposure to heavy metals in various populations can lead to extensive damage to different
organs, as these metals infiltrate and bioaccumulate in the human body, causing metabolic …

Molecular mechanisms of temperature tolerance plasticity in an arthropod

A Aagaard, J Bechsgaard, JG Sørensen… - Genome biology and …, 2024 - academic.oup.com
How species thrive in a wide range of environments is a major focus of evolutionary biology.
For many species, limited genetic diversity or gene flow among habitats means that …

Rapid Adjustments in Thermal Tolerance and the Metabolome to Daily Environmental Changes – A Field Study on the Arctic Seed Bug Nysius groenlandicus

NK Noer, MH Sørensen, H Colinet, D Renault… - Frontiers in …, 2022 - frontiersin.org
Laboratory investigations on terrestrial model-species, typically of temperate origin, have
demonstrated that terrestrial ectotherms can cope with daily temperature variations through …

Improving genomic prediction for seed quality traits in oat (Avena sativa L.) using trait-specific relationship matrices

MT Campbell, H Hu, TH Yeats, LJ Brzozowski… - Frontiers in …, 2021 - frontiersin.org
The observable phenotype is the manifestation of information that is passed along different
organization levels (transcriptional, translational, and metabolic) of a biological system. The …

Leveraging Multiple Layers of Data To Predict Drosophila Complex Traits

F Morgante, W Huang, P Sørensen… - G3: Genes …, 2020 - academic.oup.com
The ability to accurately predict complex trait phenotypes from genetic and genomic data are
critical for the implementation of personalized medicine and precision agriculture; however …

A Drosophila melanogaster model for TMEM43-related arrhythmogenic right ventricular cardiomyopathy type 5

N Klinke, H Meyer, S Ratnavadivel, M Reinhardt… - Cellular and Molecular …, 2022 - Springer
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a severe cardiac disease that
leads to heart failure or sudden cardiac death (SCD). For the pathogenesis of ARVC, various …

Comparing statistical learning methods for complex trait prediction from gene expression

N Klimkowski Arango, F Morgante - PloS one, 2025 - journals.plos.org
Accurate prediction of complex traits is an important task in quantitative genetics. Genotypes
have been used for trait prediction using a variety of methods such as mixed models …

Metabolomic spectra for phenotypic prediction of malting quality in spring barley

X Guo, A Jahoor, J Jensen, P Sarup - Scientific Reports, 2022 - nature.com
We investigated prediction of malting quality (MQ) phenotypes in different locations using
metabolomic spectra, and compared the prediction ability of different models, and training …

Multi-omics to predict changes during cold pressor test

LJA Kogelman, M Ernst, K Falkenberg, G Mazzoni… - BMC genomics, 2022 - Springer
Background The cold pressor test (CPT) is a widely used pain provocation test to investigate
both pain tolerance and cardiovascular responses. We hypothesize, that performing multi …