Type 2 diabetes in adolescents and young adults

N Lascar, J Brown, H Pattison, AH Barnett… - The lancet Diabetes & …, 2018 - thelancet.com
The prevalence of type 2 diabetes in adolescents and young adults is dramatically
increasing. Similar to older-onset type 2 diabetes, the major predisposing risk factors are …

The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives

L Chen, DJ Magliano, PZ Zimmet - Nature reviews endocrinology, 2012 - nature.com
Over the past three decades, the number of people with diabetes mellitus has more than
doubled globally, making it one of the most important public health challenges to all nations …

Diabetic retinopathy preferred practice pattern®

CJ Flaxel, RA Adelman, ST Bailey, A Fawzi, JI Lim… - …, 2020 - aaojournal.org
Background: Diabetic retinopathy is a leading cause of visual impairment in working-age
adults worldwide. Duration of diabetes is a major risk factor associated with the development …

Diabetes 2030: insights from yesterday, today, and future trends

WR Rowley, C Bezold, Y Arikan, E Byrne… - Population health …, 2017 - liebertpub.com
To forecast future trends in diabetes prevalence, morbidity, and costs in the United States,
the Institute for Alternative Futures has updated its diabetes forecasting model and extended …

SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes

JA Schaub, FM AlAkwaa, PJ McCown… - The Journal of …, 2023 - Am Soc Clin Investig
The molecular mechanisms of sodium-glucose cotransporter-2 (SGLT2) inhibitors (SGLT2i)
remain incompletely understood. Single-cell RNA sequencing and morphometric data were …

[PDF][PDF] ISPAD clinical practice consensus guidelines 2018: type 2 diabetes mellitus in youth.

P Zeitler, S Arslanian, J Fu, O Pinhas‐Hamiel… - Pediatric diabetes, 2018 - bnsde.org
1. Undiagnosed type 2 diabetes mellitus (T2DM) is rare in the adolescent population, even
among high-risk individuals (A) 2. Generalized population screening of obese youth is …

The many faces of diabetes: a disease with increasing heterogeneity

T Tuomi, N Santoro, S Caprio, M Cai, J Weng, L Groop - The Lancet, 2014 - thelancet.com
Diabetes is a much more heterogeneous disease than the present subdivision into types 1
and 2 assumes; type 1 and type 2 diabetes probably represent extremes on a range of …

The use of animal models in diabetes research

AJF King - British journal of pharmacology, 2012 - Wiley Online Library
Diabetes is a disease characterized by a relative or absolute lack of insulin, leading to
hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes …

The prevalence of obesity among children with type 2 diabetes: a systematic review and meta-analysis

M Cioana, J Deng, A Nadarajah, M Hou… - JAMA Network …, 2022 - jamanetwork.com
Importance The childhood obesity epidemic is presumed to drive pediatric type 2 diabetes
(T2D); however, the global scale of obesity in children with T2D is unknown. Objectives To …

A clinical trial to maintain glycemic control in youth with type 2 diabetes

TODAY Study Group - New England Journal of Medicine, 2012 - Mass Medical Soc
Background Despite the increasing prevalence of type 2 diabetes in youth, there are few
data to guide treatment. We compared the efficacy of three treatment regimens to achieve …