Cellular homeostasis is constantly challenged by a myriad of extrinsic and intrinsic stressors.
To mitigate the stress-induced damage, cells activate transient survival programs. The heat …

Abstract Eukaryotic RNA polymerase II (RNAPII) is responsible for the transcription of the
protein-coding genes in the cell. Enormous progress has been made in discovering the …

Eukaryotic genomes are widely transcribed by RNA polymerase II (pol II) both within genes
and in intergenic regions. POL II elongation complexes comprising the polymerase, the DNA …

Preserving and regulating cellular homeostasis in the light of changing environmental
conditions or developmental processes is of pivotal importance for single cellular and …

Transcripts produced by RNA polymerase II (RNAPII) are fundamental for cellular responses
to environmental changes. It is therefore no surprise that there exist multiple avenues for the …

Human cytomegalovirus (HCMV) primary infection, re-infection, and reactivation from
latency cause morbidity in immune-compromised patients. Consequently, potential …

Gene regulatory mechanisms that modulate RNA Polymerase II activity are difficult to access
in mammalian tissues composed of multiple cell lineages. Here, we develop a nascent RNA …

Transcriptional reprogramming drives differentiation and coordinates cellular responses.
While mRNA expression in distinct cell types has been extensively analyzed, the …

The Aedes aegypti mosquito transmits arboviruses such as dengue, Zika, and chikungunya
virus, posing a substantial threat to global health. The mosquito immune response …

Transcriptional regulation in eukaryotes is a highly coordinated process involving the
interplay between chromatin remodeling and RNA Polymerase II (RNA Pol II). Chromatin …