Re-examining the Mysterious Role of the Cerebellum in Pain

CN Li, KA Keay, LA Henderson… - Journal of …, 2024 - Soc Neuroscience
Pain is considered a multidimensional experience that embodies not merely sensation, but
also emotion and perception. As is appropriate for this complexity, pain is represented and …

Cognitive-affective functions of the cerebellum

S Rudolph, A Badura, S Lutzu, SS Pathak… - Journal of …, 2023 - Soc Neuroscience
The cerebellum, traditionally associated with motor coordination and balance, also plays a
crucial role in various aspects of higher-order function and dysfunction. Emerging research …

Memory trace for fear extinction: fragile yet reinforceable

Y Liu, S Ye, XN Li, WG Li - Neuroscience Bulletin, 2024 - Springer
Fear extinction is a biological process in which learned fear behavior diminishes without
anticipated reinforcement, allowing the organism to re-adapt to ever-changing situations …

A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain

CH Chen, LN Newman, AP Stark, KE Bond… - Nature …, 2023 - nature.com
In addition to its motor functions, the cerebellum is involved in emotional regulation, anxiety
and affect. We found that suppressing the firing of cerebellar Purkinje cells (PCs) rapidly …

Cerebellar control of fear learning via the cerebellar nuclei–Multiple pathways, multiple mechanisms?

JD Urrutia Desmaison, RW Sala, A Ayyaz… - Frontiers in Systems …, 2023 - frontiersin.org
Fear learning is mediated by a large network of brain structures and the understanding of
their roles and interactions is constantly progressing. There is a multitude of anatomical and …

Selection for reduced fear of humans changes brain and cerebellum size in red junglefowl in line with effects of chicken domestication

J Gjøen, F Cunha, P Jensen - Brain Sciences, 2023 - mdpi.com
A central part of the domestication syndrome is a reduction in relative brain size. In chickens,
it has previously been shown that domesticated birds have smaller relative brain mass, but …

Intrinsic plasticity of Purkinje cell serves homeostatic regulation of fear memory

J Lee, SH Kim, DC Jang, M Jang, MS Bak… - Molecular …, 2024 - nature.com
Two forms of plasticity, synaptic and intrinsic, are neural substrates for learning and memory.
Abnormalities in homeostatic plasticity cause severe neuropsychiatric diseases, such as …

Cerebellar output neurons impair non-motor behaviors by altering development of extracerebellar connectivity

AS Lee, TM Arefin, A Gubanova, DN Stephen, Y Liu… - …, 2024 - pmc.ncbi.nlm.nih.gov
The capacity of the brain to compensate for insults during development depends on the type
of cell loss, whereas the consequences of genetic mutations in the same neurons are …

CK2 negatively regulates the extinction of remote fear memory

J Yang, L Lin, GJ Zou, LF Wang, F Li, CQ Li… - Behavioural Brain …, 2024 - Elsevier
Cognitive behavioral therapy, rooted in exposure therapy, is currently the primary approach
employed in the treatment of anxiety-related conditions, including post-traumatic stress …

The cerebellum and its connections to other brain structures involved in motor and non-motor functions: a comprehensive review

JM Prati, A Pontes-Silva, ACL Gianlorenço - Behavioural Brain Research, 2024 - Elsevier
The cerebellum has a large network of neurons that communicate with several brain
structures and participate in different functions. Recent studies have demonstrated that the …