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Diverse functions of cytochrome c in cell death and disease
The redox-active protein cytochrome c is a highly positively charged hemoglobin that
regulates cell fate decisions of life and death. Under normal physiological conditions …
regulates cell fate decisions of life and death. Under normal physiological conditions …
Mitochondrial dysfunction in inherited renal disease and acute kidney injury
Mitochondria are increasingly recognized as key players in genetic and acquired renal
diseases. Most mitochondrial cytopathies that cause renal symptoms are characterized by …
diseases. Most mitochondrial cytopathies that cause renal symptoms are characterized by …
[HTML][HTML] Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis
Cytochrome c (Cytc) plays a vital role in the mitochondrial electron transport chain (ETC). In
addition, it is a key regulator of apoptosis. Cytc has multiple other functions including ROS …
addition, it is a key regulator of apoptosis. Cytc has multiple other functions including ROS …
Multifunctional Cytochrome c: Learning New Tricks from an Old Dog
Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively flexible
structure, particularly in the ferric form, such that it is able to sample a broad conformational …
structure, particularly in the ferric form, such that it is able to sample a broad conformational …
Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation
Platelets are essential for haemostasis, and thrombocytopenia (platelet counts< 150× 109/l)
is a major clinical problem encountered across a number of conditions, including immune …
is a major clinical problem encountered across a number of conditions, including immune …
Inherited platelet disorders: an updated overview
V Palma-Barqueros, N Revilla, A Sánchez… - International journal of …, 2021 - mdpi.com
Platelets play a major role in hemostasis as ppwell as in many other physiological and
pathological processes. Accordingly, production of about 1011 platelet per day as well as …
pathological processes. Accordingly, production of about 1011 platelet per day as well as …
Mutations in the 5′ UTR of ANKRD26, the ankirin repeat domain 26 gene, cause an autosomal-dominant form of inherited thrombocytopenia, THC2
THC2, an autosomal-dominant thrombocytopenia described so far in only two families, has
been ascribed to mutations in MASTL or ACBD5. Here, we show that ANKRD26, another …
been ascribed to mutations in MASTL or ACBD5. Here, we show that ANKRD26, another …
Apoptosis in megakaryocytes and platelets: the life and death of a lineage
Despite their profoundly different cellular composition, size, and function, megakaryocytes
and platelets both depend on restraint of the intrinsic (or “mitochondrial”) apoptosis pathway …
and platelets both depend on restraint of the intrinsic (or “mitochondrial”) apoptosis pathway …
Hereditary thrombocytopenias: a growing list of disorders
P Noris, A Pecci - Hematology 2014, the American Society of …, 2017 - ashpublications.org
The introduction of high throughput sequencing (HTS) techniques greatly improved the
knowledge of inherited thrombocytopenias (ITs) over the last few years. A total of 33 different …
knowledge of inherited thrombocytopenias (ITs) over the last few years. A total of 33 different …
Inherited platelet disorders: toward DNA-based diagnosis
Variations in platelet number, volume, and function are largely genetically controlled, and
many loci associated with platelet traits have been identified by genome-wide association …
many loci associated with platelet traits have been identified by genome-wide association …