The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large‐scale resting‐state functional brain networks in aging

HA Deery, R Di Paolo, C Moran, GF Egan… - …, 2023 - Wiley Online Library
The literature on large‐scale resting‐state functional brain networks across the adult
lifespan was systematically reviewed. Studies published between 1986 and July 2021 were …

Resting-state networks in the course of aging—differential insights from studies across the lifespan vs. amongst the old

C Jockwitz, S Caspers - Pflügers Archiv-European Journal of Physiology, 2021 - Springer
Resting-state functional connectivity (RSFC) has widely been used to examine
reorganization of functional brain networks during normal aging. The extraction of …

[HTML][HTML] Patterns of functional connectivity in an aging population: The Rotterdam Study

HI Zonneveld, RHR Pruim, D Bos, HA Vrooman… - Neuroimage, 2019 - Elsevier
Structural brain markers are studied extensively in the field of neurodegeneration, but are
thought to occur rather late in the process. Functional measures such as functional …

[HTML][HTML] Functional network reorganization in older adults: Graph-theoretical analyses of age, cognition and sex

J Stumme, C Jockwitz, F Hoffstaedter, K Amunts… - NeuroImage, 2020 - Elsevier
Healthy aging has been associated with a decrease in functional network specialization.
Importantly, variability of alterations of functional connectivity is especially high across older …

Is it time to put rest to rest?

ES Finn - Trends in cognitive sciences, 2021 - cell.com
The so-called resting state, in which participants lie quietly with no particular inputs or
outputs, represented a paradigm shift from conventional task-based studies in human …

Machine-learning identifies Parkinson's disease patients based on resting-state between-network functional connectivity

C Rubbert, C Mathys, C Jockwitz… - The british journal of …, 2019 - academic.oup.com
Objective: Evaluation of a data-driven, model-based classification approach to discriminate
idiopathic Parkinson's disease (PD) patients from healthy controls (HC) based on between …

[HTML][HTML] Effect of channel density, inverse solutions and connectivity measures on EEG resting-state networks reconstruction: A simulation study

S Allouch, A Kabbara, J Duprez, M Khalil, J Modolo… - NeuroImage, 2023 - Elsevier
Along with the study of brain activity evoked by external stimuli, the past two decades
witnessed an increased interest in characterizing the spontaneous brain activity occurring …

[HTML][HTML] Synaptic signaling modeled by functional connectivity predicts metabolic demands of the human brain

S Klug, M Murgaš, GM Godbersen, M Hacker… - NeuroImage, 2024 - Elsevier
Purpose The human brain is characterized by interacting large-scale functional networks
fueled by glucose metabolism. Since former studies could not sufficiently clarify how these …

Neurocognitive profiles of older adults with working-memory dysfunction

A Salami, A Rieckmann, N Karalija… - Cerebral …, 2018 - academic.oup.com
Individuals differ in how they perceive, remember, and think. There is evidence for the
existence of distinct subgroups that differ in cognitive performance within the older …

White-matter degradation and dynamical compensation support age-related functional alterations in human brain

S Petkoski, P Ritter, VK Jirsa - Cerebral Cortex, 2023 - academic.oup.com
Structural connectivity of the brain at different ages is analyzed using diffusion-weighted
magnetic resonance imaging (MRI) data. The largest decrease of streamlines is found in …