Summary With a prevalence of 10–15% in adults in Europe and the USA, gallstones are the
most common digestive disease needing admission to hospital in the West. The interplay …

The cosolvency models presented from 1960 to 2007 were reviewed and their accuracies
for correlating and/or predicting the solubility of drugs in water-cosolvent mixtures were …

Aqueous solubility is one of the major challenges in the early stages of drug discovery. One
of the most common and effective methods for enhancing solubility is the addition of an …

The use of Doppler studies of the uterine arteries in the prediction of pre‐eclampsia and
intrauterine growth retardation has had mixed success. The introduction of color Doppler …

Gallstone disease is one of the most prevalent gastrointestinal diseases with a substantial
burden to health care systems that is supposed to increase in ageing populations at risk …

Gallstone disease is a worldwide medical problem, but the incidence rates show substantial
geographical variation, with the lowest rates reported in African populations. Publications in …

Gallstones are a major cause of morbidity and mortality throughout the world. In the United
States alone, the diagnosis and treatment of gallstone disease accounted for more than $5 …

Although an association between gallstones and pancreatitis has been recognized for
almost 100 years, the risk of acute pancreatitis in patients with gallstones and the effect of …

The increasing detection of asymptomatic gallstones leads to difficult decisions for the
surgeon and patient about whether the stones should be managed expectantly or surgically …

Common bile duct stones (CBDSs) may occur in up to 3%–14.7% of all patients for whom
cholecystectomy is preformed. Patients presenting with CBDS have symptoms including …