The neurobiology of activational aspects of motivation: exertion of effort, effort-based decision making, and the role of dopamine

JD Salamone, M Correa - Annual review of psychology, 2024 - annualreviews.org
Motivational processes are complex and multifaceted, with both directional and activational
aspects. Behavioral activation and exertion of effort are functions that enable organisms to …

Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work

A Westbrook, R Van Den Bosch, JI Määttä, L Hofmans… - Science, 2020 - science.org
Stimulants such as methylphenidate are increasingly used for cognitive enhancement but
precise mechanisms are unknown. We found that methylphenidate boosts willingness to …

Dissociable motivational deficits in pre-manifest Huntington's disease

KJ Atkins, SC Andrews, JC Stout, TTJ Chong - Cell Reports Medicine, 2020 - cell.com
Motivation is characterized by a willingness to overcome both cognitive and physical effort
costs. Impairments in motivation are common in striatal disorders, such as Huntington's …

Dissociable mechanisms underpinning effort-cost decision-making across the psychosis spectrum

AE Whitton, JT Merchant, KE Lewandowski - Schizophrenia Research, 2020 - Elsevier
Recent theoretical models propose that abnormal effort-cost decision-making (ECDM) likely
has divergent underpinnings across mood and psychotic disorders. However, whether this …

Dorsomedial striatal contributions to different forms of risk/reward decision making

JD Schumacher, M van Holstein, V Bagrodia… - … of Learning and …, 2021 - Elsevier
Optimal decision making involving reward uncertainty is integral to adaptive goal-directed
behavior. In some instances, these decisions are guided by internal representations of …

Insight into differing decision-making strategies that underlie cognitively effort-based decision making using computational modeling in rats

CA Hales, MM Silveira, L Calderhead, L Mortazavi… - …, 2024 - Springer
Rationale The rat cognitive effort task (rCET), a rodent model of cognitive rather than
physical effort, requires animals to choose between an easy or hard visuospatial …

Investigating serotonergic contributions to cognitive effort allocation, attention, and impulsive action in female rats

MM Silveira, SN Wittekindt… - Journal of …, 2020 - journals.sagepub.com
Background: Individuals must frequently evaluate whether it is worth allocating cognitive
effort for desired outcomes. Motivational deficits are a common feature of psychiatric illness …

Evaluation of cognitive effort in rats is not critically dependent on ventrolateral orbitofrontal cortex

MM Silveira, SN Wittekindt, S Ebsary… - European Journal of …, 2021 - Wiley Online Library
Organisms must frequently evaluate the amount of effort to invest in pursuing future rewards.
Despite explicit awareness of the potential benefits of cognitive work, individuals vary in their …

Anabolic-androgenic steroids and cognitive effort discounting in male rats

LB Dokovna, G Li, RI Wood - Hormones and behavior, 2019 - Elsevier
Anabolic-androgenic steroids (AAS) are drugs of abuse that impair behavior and cognition.
In a rodent model of AAS abuse, testosterone-treated male rats expend more physical effort …

Value coding in the pigeon nidopallium caudolaterale

MM Dykes - 2020 - ourarchive.otago.ac.nz
Until recently, the avian brain has remained relatively unexplored by neuroscientists.
However, as reports of evidence of high-order behaviour in birds has increased, the avian …