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[PDF][PDF] The cancer genome atlas pan-cancer analysis project
Abstract The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed
large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein …
large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein …
Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo
Adeno-associated virus (AAV) vectors are important delivery platforms for therapeutic
genome editing but are severely constrained by cargo limits. Simultaneous delivery of …
genome editing but are severely constrained by cargo limits. Simultaneous delivery of …
Glucose and amino acid metabolic dependencies linked to stemness and metastasis in different aggressive cancer types
A Chisari, I Golán, S Campisano, C Gélabert… - Frontiers in …, 2021 - frontiersin.org
Malignant cells are commonly characterised by being capable of invading tissue, growing
self-sufficiently and uncontrollably, being insensitive to apoptosis induction and controlling …
self-sufficiently and uncontrollably, being insensitive to apoptosis induction and controlling …
A dual-emission ratiometric fluorescence capillary imprinted sensor based on metal-organic frameworks for sensitive detection of L-tyrosine
S Tang, P Zhao, X Wu, Y Chen, K Tang, S Zhou… - Sensors and Actuators B …, 2022 - Elsevier
A novel dual-emission ratiometric fluorescence capillary imprinted sensor based on
luminescence metal organic framework was fabricated firstly with high sensitivity and …
luminescence metal organic framework was fabricated firstly with high sensitivity and …
[HTML][HTML] Transcriptomic harmonization as the way for suppressing cross-platform bias and batch effect
(1) Background: Emergence of methods interrogating gene expression at high throughput
gave birth to quantitative transcriptomics, but also posed a question of inter-comparison of …
gave birth to quantitative transcriptomics, but also posed a question of inter-comparison of …
Identification and validation of a tyrosine metabolism-related prognostic prediction model and characterization of the tumor microenvironment infiltration in …
Y Zhou, X Li, G Long, Y Tao, L Zhou… - Frontiers in Immunology, 2022 - frontiersin.org
Background Hepatocellular carcinoma (HCC) is an aggressive and heterogeneous disease
characterized by high morbidity and mortality. The liver is the vital organ that participates in …
characterized by high morbidity and mortality. The liver is the vital organ that participates in …
A multi-omic analysis reveals that Gamabufotalin exerts anti-hepatocellular carcinoma effects by regulating amino acid metabolism through targeting STAMBPL1
P Zheng, D Xu, Y Cai, L Zhu, Q **ao, W Peng, B Chen - Phytomedicine, 2024 - Elsevier
Background Hepatocellular carcinoma (HCC), a prevalent type of liver cancer, is
characterized by an unfavorable prognosis and a high mortality rate. Identifying novel …
characterized by an unfavorable prognosis and a high mortality rate. Identifying novel …
TRIM21-mediated ubiquitylation of TAT suppresses liver metastasis in gallbladder cancer
Z Wu, J Zhang, Z Jia, Z Yang, S Liu, H Wang, C Zhao… - Cancer Letters, 2024 - Elsevier
Liver metastasis is common in patients with gallbladder cancer (GBC), imposing a significant
challenge in clinical management and serving as a poor prognostic indicator. However, the …
challenge in clinical management and serving as a poor prognostic indicator. However, the …
[HTML][HTML] Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer
The liver plays central roles in coordinating different metabolic processes, such as the
catabolism of amino acids. In this study, we identify a loss of tyrosine catabolism and a …
catabolism of amino acids. In this study, we identify a loss of tyrosine catabolism and a …
TPO as an indicator of lymph node metastasis and recurrence in papillary thyroid carcinoma
X Li, R Cheng - Scientific Reports, 2023 - nature.com
The objective of this study was to investigate the expression of thyroid peroxidase (TPO) in
papillary thyroid carcinoma (PTC) and to preliminarily investigate its value as a marker of …
papillary thyroid carcinoma (PTC) and to preliminarily investigate its value as a marker of …