[PDF][PDF] The cancer genome atlas pan-cancer analysis project

JN Weinstein, EA Collisson, GB Mills, KR Shaw… - Nature …, 2013 - nature.com
Abstract The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed
large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein …

Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo

R Ibraheim, PWL Tai, A Mir, N Javeed, J Wang… - Nature …, 2021 - nature.com
Adeno-associated virus (AAV) vectors are important delivery platforms for therapeutic
genome editing but are severely constrained by cargo limits. Simultaneous delivery of …

Glucose and amino acid metabolic dependencies linked to stemness and metastasis in different aggressive cancer types

A Chisari, I Golán, S Campisano, C Gélabert… - Frontiers in …, 2021 - frontiersin.org
Malignant cells are commonly characterised by being capable of invading tissue, growing
self-sufficiently and uncontrollably, being insensitive to apoptosis induction and controlling …

A dual-emission ratiometric fluorescence capillary imprinted sensor based on metal-organic frameworks for sensitive detection of L-tyrosine

S Tang, P Zhao, X Wu, Y Chen, K Tang, S Zhou… - Sensors and Actuators B …, 2022 - Elsevier
A novel dual-emission ratiometric fluorescence capillary imprinted sensor based on
luminescence metal organic framework was fabricated firstly with high sensitivity and …

[HTML][HTML] Transcriptomic harmonization as the way for suppressing cross-platform bias and batch effect

N Borisov, A Buzdin - Biomedicines, 2022 - mdpi.com
(1) Background: Emergence of methods interrogating gene expression at high throughput
gave birth to quantitative transcriptomics, but also posed a question of inter-comparison of …

Identification and validation of a tyrosine metabolism-related prognostic prediction model and characterization of the tumor microenvironment infiltration in …

Y Zhou, X Li, G Long, Y Tao, L Zhou… - Frontiers in Immunology, 2022 - frontiersin.org
Background Hepatocellular carcinoma (HCC) is an aggressive and heterogeneous disease
characterized by high morbidity and mortality. The liver is the vital organ that participates in …

A multi-omic analysis reveals that Gamabufotalin exerts anti-hepatocellular carcinoma effects by regulating amino acid metabolism through targeting STAMBPL1

P Zheng, D Xu, Y Cai, L Zhu, Q **ao, W Peng, B Chen - Phytomedicine, 2024 - Elsevier
Background Hepatocellular carcinoma (HCC), a prevalent type of liver cancer, is
characterized by an unfavorable prognosis and a high mortality rate. Identifying novel …

TRIM21-mediated ubiquitylation of TAT suppresses liver metastasis in gallbladder cancer

Z Wu, J Zhang, Z Jia, Z Yang, S Liu, H Wang, C Zhao… - Cancer Letters, 2024 - Elsevier
Liver metastasis is common in patients with gallbladder cancer (GBC), imposing a significant
challenge in clinical management and serving as a poor prognostic indicator. However, the …

[HTML][HTML] Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer

M Tong, TL Wong, H Zhao, Y Zheng, YN **e, CH Li… - Cell reports, 2021 - cell.com
The liver plays central roles in coordinating different metabolic processes, such as the
catabolism of amino acids. In this study, we identify a loss of tyrosine catabolism and a …

TPO as an indicator of lymph node metastasis and recurrence in papillary thyroid carcinoma

X Li, R Cheng - Scientific Reports, 2023 - nature.com
The objective of this study was to investigate the expression of thyroid peroxidase (TPO) in
papillary thyroid carcinoma (PTC) and to preliminarily investigate its value as a marker of …