The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and
holds great promise to advance regenerative medicine. iPSCs have the capacity for an …

The assay for transposase-accessible chromatin using sequencing (ATAC-seq) provides a
simple and scalable way to detect the unique chromatin landscape associated with a cell …

The ubiquitous family of AP-1 dimeric transcription complexes is involved in virtually all
cellular and physiological functions. It is paramount for cells to reprogram gene expression …

Recent efforts have succeeded in surveying open chromatin at the single-cell level, but high-
throughput, single-cell assessment of heterochromatin and its underlying genomic …

Somatic cell reprogramming provides insight into basic principles of cell fate determination,
which remain poorly understood. Here we show that the transcription factor Glis1 induces …

Transposable elements (TEs) make up a majority of a typical eukaryote's genome, and
contribute to cell heterogeneity in unclear ways. Single-cell sequencing technologies are …

Our understanding of pluripotency remains limited: iPSC generation has only been
established for a few model species, pluripotent stem cell lines exhibit inconsistent …

The process of induced pluripotent stem cells (iPSCs) reprogramming involves several
crucial events, including the mesenchymal-epithelial transition (MET), activation of …

Cell fate transitions are accompanied by global transcriptional, epigenetic and topological
changes driven by transcription factors, as is exemplified by reprogramming somatic cells to …

Over the past decade, there has been a dramatic increase in efforts to ameliorate aging and
the diseases it causes, with transient expression of nuclear reprogramming factors recently …