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mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
Mammalian target of rapamycin (mTOR) regulates cell proliferation, autophagy, and
apoptosis by participating in multiple signaling pathways in the body. Studies have shown …
apoptosis by participating in multiple signaling pathways in the body. Studies have shown …
[HTML][HTML] Cancer immunotherapy: Pros, cons and beyond
Cancer immunotherapy is an innovative treatment for tumors today. In various experiments
and clinical studies, it has been found that immunotherapy does have incomparable …
and clinical studies, it has been found that immunotherapy does have incomparable …
Microsatellite instability: a review of what the oncologist should know
The patients with high microsatellite instability (MSI-H)/mismatch repair deficient (dMMR)
tumors recently have been reported that can benefit from immunotherapy, and MSI can be …
tumors recently have been reported that can benefit from immunotherapy, and MSI can be …
Mechanisms of immune checkpoint inhibitors: Insights into the regulation of circular RNAS involved in cancer hallmarks
L Meng, H Wu, J Wu, P Ding, J He, M Sang… - Cell Death & Disease, 2024 - nature.com
Current treatment strategies for cancer, especially advanced cancer, are limited and
unsatisfactory. One of the most substantial advances in cancer therapy, in the last decades …
unsatisfactory. One of the most substantial advances in cancer therapy, in the last decades …
Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression
Abstract Background Although both circular RNAs (circRNAs) and autophagy are associated
with the function of breast cancer (BC), whether circRNAs regulate BC progression via …
with the function of breast cancer (BC), whether circRNAs regulate BC progression via …
[HTML][HTML] The metastasizing mechanisms of lung cancer: Recent advances and therapeutic challenges
Lung cancer is one of the common malignant tumors that threaten human life with serious
incidence and high mortality. According to the histopathological characteristics, lung cancer …
incidence and high mortality. According to the histopathological characteristics, lung cancer …
[HTML][HTML] Tumor-infiltrating lymphocytes: Warriors fight against tumors powerfully
Tumor-infiltrating lymphocytes (TILs) are infiltrating lymphocytes in tumor tissues. After
isolation, screening and amplification in vitro, they will be implanted into patients and play a …
isolation, screening and amplification in vitro, they will be implanted into patients and play a …
[HTML][HTML] Nanomedicines: redefining traditional medicine
Nanomedicines offer nanoscale drug delivery system. They offer ways of promising drug
transportation, and address the issues of lack of targeting and permeability of traditional …
transportation, and address the issues of lack of targeting and permeability of traditional …
Circular RNA circBCBM1 promotes breast cancer brain metastasis by modulating miR-125a/BRD4 axis
B Fu, W Liu, C Zhu, P Li, L Wang, L Pan… - … journal of biological …, 2021 - pmc.ncbi.nlm.nih.gov
Circular RNAs (circRNAs) play critical roles in tumorigenesis and the progression of various
cancers. We previously identified a novel upregulated circRNA, circBCBM1 …
cancers. We previously identified a novel upregulated circRNA, circBCBM1 …
[HTML][HTML] Breakthrough in targeted therapy for non-small cell lung cancer
Non-small cell lung cancer (NSCLC) remains by far the single most common malignancy of
lung cancer which causes more and more mortality in recent years. NSCLC accounts for …
lung cancer which causes more and more mortality in recent years. NSCLC accounts for …