Microsatellites, or tandem simple sequence repeats (SSR), are abundant across genomes
and show high levels of polymorphism. SSR genetic and evolutionary mechanisms remain …

Of the new generation platinum compounds that have been evaluated, those with the 1, 2-
diaminocyclohexane carrier ligand–including oxaliplatin–have been focused upon in recent …

At a time of unprecedented expansion in the life sciences, evolution is the one theory that
transcends all of biology. Any observation of a living system must ultimately be interpreted in …

Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite
instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island …

Somatic mutations in DNA mismatch repair genes have been observed in sporadic tumors
as well as cell lines and xenografts derived from such tumors implicating genetic defects of …

Cancer chemotherapeutic agents such as cisplatin exert their cytotoxic effect by inducing
DNA damage and activating programmed cell death (apoptosis). The tumour-suppressor …

Mutations of DNA mismatch repair genes, including the hMLH1 gene, have been linked to
human colon and other cancers in which defective DNA repair is evidenced by the …

The genetic and biochemical properties of three human MutS homologues, hMSH2, hMSH3,
and hMSH6, have been examined. The full-length hMSH6 cDNA and genomic locus were …

Germ line mutations in DNA mismatch repair genes including MLH1 cause hereditary
nonpolyposis colon cancer. To understand the role of MLH1 in normal growth and …

Saccharomyces cerevisiae encodes six genes, MSH1-6, which encode proteins related to
the bacterial MutS protein. In this study the role of MSH2, MSH3, and MSH6 in mismatch …