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Toxoplasma gondii infection and its implications within the central nervous system
SK Matta, N Rinkenberger, IR Dunay… - Nature Reviews …, 2021 - nature.com
Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic
infections in humans. Although it normally only results in mild illness in healthy individuals …
infections in humans. Although it normally only results in mild illness in healthy individuals …
Toxoplasma Effectors Targeting Host Signaling and Transcription
Early electron microscopy studies revealed the elaborate cellular features that define the
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …
Modulation of innate immunity by Toxoplasma gondii virulence effectors
Toxoplasma gondii is a common parasite of animals and humans and can cause serious
opportunistic infections. However, the majority of infections are asymptomatic, possibly …
opportunistic infections. However, the majority of infections are asymptomatic, possibly …
Polymorphic secreted kinases are key virulence factors in toxoplasmosis
The majority of known Toxoplasma gondii isolates from Europe and North America belong to
three clonal lines that differ dramatically in their virulence, depending on the host. To identify …
three clonal lines that differ dramatically in their virulence, depending on the host. To identify …
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue
Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa, can cause
severe disease in humans with an immature or suppressed immune system. The outcome of …
severe disease in humans with an immature or suppressed immune system. The outcome of …
The moving junction of apicomplexan parasites: a key structure for invasion
S Besteiro, JF Dubremetz, M Lebrun - Cellular microbiology, 2011 - Wiley Online Library
Most Apicomplexa are obligate intracellular parasites and many are important pathogens of
human and domestic animals. For a successful cell invasion, they rely on their own motility …
human and domestic animals. For a successful cell invasion, they rely on their own motility …
ToxoDB: an integrated Toxoplasma gondii database resource
B Gajria, A Bahl, J Brestelli, J Dommer… - Nucleic acids …, 2007 - academic.oup.com
Abstract ToxoDB (http://ToxoDB. org) is a genome and functional genomic database for the
protozoan parasite Toxoplasma gondii. It incorporates the sequence and annotation of the T …
protozoan parasite Toxoplasma gondii. It incorporates the sequence and annotation of the T …
A Secreted Serine-Threonine Kinase Determines Virulence in the Eukaryotic Pathogen Toxoplasma gondii
Toxoplasma gondii strains differ dramatically in virulence despite being genetically very
similar. Genetic map** revealed two closely adjacent quantitative trait loci on parasite …
similar. Genetic map** revealed two closely adjacent quantitative trait loci on parasite …
The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice
Polymorphic rhoptry-secreted kinases (ROPs) are essential virulence factors of Toxoplasma
gondii. In particular, the pseudokinase ROP5 is the major determinant of acute virulence in …
gondii. In particular, the pseudokinase ROP5 is the major determinant of acute virulence in …
Identification of the Moving Junction Complex of Toxoplasma gondii: A Collaboration between Distinct Secretory Organelles
DL Alexander, J Mital, GE Ward, P Bradley… - PLoS …, 2005 - journals.plos.org
Apicomplexan parasites, including Toxoplasma gondii and Plasmodium sp., are obligate
intracellular protozoa. They enter into a host cell by attaching to and then creating an …
intracellular protozoa. They enter into a host cell by attaching to and then creating an …