Toxoplasma gondii infection and its implications within the central nervous system

SK Matta, N Rinkenberger, IR Dunay… - Nature Reviews …, 2021 - nature.com
Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic
infections in humans. Although it normally only results in mild illness in healthy individuals …

Toxoplasma Effectors Targeting Host Signaling and Transcription

MA Hakimi, P Olias, LD Sibley - Clinical microbiology reviews, 2017 - journals.asm.org
Early electron microscopy studies revealed the elaborate cellular features that define the
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …

Modulation of innate immunity by Toxoplasma gondii virulence effectors

CA Hunter, LD Sibley - Nature Reviews Microbiology, 2012 - nature.com
Toxoplasma gondii is a common parasite of animals and humans and can cause serious
opportunistic infections. However, the majority of infections are asymptomatic, possibly …

Polymorphic secreted kinases are key virulence factors in toxoplasmosis

JPJ Saeij, JP Boyle, S Coller, S Taylor, LD Sibley… - Science, 2006 - science.org
The majority of known Toxoplasma gondii isolates from Europe and North America belong to
three clonal lines that differ dramatically in their virulence, depending on the host. To identify …

Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue

JPJ Saeij, S Coller, JP Boyle, ME Jerome, MW White… - Nature, 2007 - nature.com
Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa, can cause
severe disease in humans with an immature or suppressed immune system. The outcome of …

The moving junction of apicomplexan parasites: a key structure for invasion

S Besteiro, JF Dubremetz, M Lebrun - Cellular microbiology, 2011 - Wiley Online Library
Most Apicomplexa are obligate intracellular parasites and many are important pathogens of
human and domestic animals. For a successful cell invasion, they rely on their own motility …

ToxoDB: an integrated Toxoplasma gondii database resource

B Gajria, A Bahl, J Brestelli, J Dommer… - Nucleic acids …, 2007 - academic.oup.com
Abstract ToxoDB (http://ToxoDB. org) is a genome and functional genomic database for the
protozoan parasite Toxoplasma gondii. It incorporates the sequence and annotation of the T …

A Secreted Serine-Threonine Kinase Determines Virulence in the Eukaryotic Pathogen Toxoplasma gondii

S Taylor, A Barragan, C Su, B Fux, SJ Fentress, K Tang… - Science, 2006 - science.org
Toxoplasma gondii strains differ dramatically in virulence despite being genetically very
similar. Genetic map** revealed two closely adjacent quantitative trait loci on parasite …

The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice

RD Etheridge, A Alaganan, K Tang, HJ Lou, BE Turk… - Cell host & …, 2014 - cell.com
Polymorphic rhoptry-secreted kinases (ROPs) are essential virulence factors of Toxoplasma
gondii. In particular, the pseudokinase ROP5 is the major determinant of acute virulence in …

Identification of the Moving Junction Complex of Toxoplasma gondii: A Collaboration between Distinct Secretory Organelles

DL Alexander, J Mital, GE Ward, P Bradley… - PLoS …, 2005 - journals.plos.org
Apicomplexan parasites, including Toxoplasma gondii and Plasmodium sp., are obligate
intracellular protozoa. They enter into a host cell by attaching to and then creating an …