Drug discovery is adapting to novel technologies such as data science, informatics, and
artificial intelligence (AI) to accelerate effective treatment development while reducing costs …

Autophagy (macroautophagy) is a highly conserved intracellular and lysosome-dependent
degradation process in which autophagic substrates are enclosed and degraded by a …

Premature ovarian insufficiency (POI) is a major cause of female infertility due to early loss of
ovarian function. POI is a heterogeneous condition, and its molecular etiology is unclear. To …

Many researchers, especially those new to the field, need to determine which criteria are
essential for demonstrating autophagy, either for the purposes of their own research, or in …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

In solid tumors, cancer stem cells (CSCs) or tumor-initiating cells (TICs) are often found in
hypoxic niches. Nevertheless, the influence of hypoxia on TICs is poorly understood. Using …

Disturbances in autophagy and stress granule dynamics have been implicated as potential
mechanisms underlying inclusion body myopathy (IBM) and related disorders. Yet the roles …

Autophagy is a process preserving the balance between synthesis, degradation and
recycling of cellular components and is therefore essential for neuronal survival and …

Glioblastoma multiforme is the most common and the most aggressive primary brain tumor. It
is characterized by a high degree of hypoxia and also by a remarkable resistance to therapy …