The poor dissolution characteristics of water-insoluble drugs are a major challenge for
pharmaceutical scientists. Reduction of the particle size/increase in the surface area of the …

We report on a porous silica–lipid hybrid microcapsule (SLH) oral delivery system for
indomethacin fabricated from Pickering emulsion templates, where the drug forms an …

Solid dispersions of active pharmaceutical ingredients are of increasing interest due to their
versatile use. In the present study polyvinylpyrrolidone (PVP), poly [N-(2-hydroxypropyl) …

There are many methods to increase solubility of a substance. These include, inter alia,
preparation of solid dispersions, ie eutectic mixtures, solid solutions, glassy solutions and …

Poorly water-soluble weakly basic compounds which are solubilized in gastric fluid are likely
to precipitate after the solution empties from the stomach into the small intestine, leading to a …

Solid dispersions is an efficient means of improving the dissolution rate and hence the
bioavailability of a range of poorly soluble drugs. This article reviews the various types of …

Understanding the crystallization kinetics of an amorphous drug is critical for the
development of an amorphous solid dispersion (ASD) formulation. This paper examines the …

The aim of the present study was to prepare solid dispersion (SD) of Lansoprazole (LSP) to
improve its saturation solubility and dissolution. SDs were prepared with a hydrophiphilic …

Hydrochlorothiazide (HCTZ), which was developed and introduced in the late 1950s, is still
one of the most frequently employed drugs in antihypertensive treatments. Its poor aqueous …

Purpose: The aim of the present study was to formulate solid dispersion (SD) of Mesalamine
to enrich the aqueous solubility and dissolution rate. Mesalamine is used in the …