Cellular senescence is defined as irreversible cell cycle arrest caused by various processes
that render viable cells non-functional, hampering normal tissue homeostasis. It has many …

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide,
but credible estimates from the World Health Organization and the International Agency for …

The tumour suppressor p53 is a transcription factor that has evolved the ability to integrate
distinct environmental signals including DNA damage, virus infection, and cytokine signaling …

The coordinated and reciprocal action of serine-threonine protein kinases and protein
phosphatases produces transitory phosphorylation, a fundamental regulatory mechanism for …

Cancer cells take advantage of signaling cascades to meet their requirements for sustained
growth and survival. Cell signaling is tightly controlled by reversible protein phosphorylation …

Cellular senescence is a tumor suppression mechanism that evolved to limit duplication in
somatic cells. Senescence is imposed by natural replicative boundaries or stress-induced …

Sarcomas are malignant tumors accounting for a high percentage of cancer morbidity and
mortality in children and young adults. Surgery and radiation therapy are the accepted …

Background: Primary radiotherapy (RT) is a mainstay of treatment for laryngeal squamous
cell carcinoma (LSCC). Although the cure rates for early (T1) vocal cord tumours are high …

Senescence is a complex cellular process that is implicated in various physiological and
pathological processes. It is characterized by a stable state of cell growth arrest and by a …

Oncogene-induced senescence (OIS) is a form of stable cell-cycle arrest arising in response
to oncogenic stimulation. OIS must be bypassed for transformation, but the mechanisms of …