Establishment and dysfunction of the blood-brain barrier

Z Zhao, AR Nelson, C Betsholtz, BV Zlokovic - Cell, 2015 - cell.com
Structural and functional brain connectivity, synaptic activity, and information processing
require highly coordinated signal transduction between different cell types within the …

Pericytes of the neurovascular unit: key functions and signaling pathways

MD Sweeney, S Ayyadurai, BV Zlokovic - Nature neuroscience, 2016 - nature.com
Pericytes are vascular mural cells embedded in the basement membrane of blood
microvessels. They extend their processes along capillaries, pre-capillary arterioles and …

Medial Arterial Calcification: JACC State-of-the-Art Review

P Lanzer, FM Hannan, JD Lanzer, J Janzen… - Journal of the American …, 2021 - jacc.org
Medial arterial calcification (MAC) is a chronic systemic vascular disorder distinct from
atherosclerosis that is frequently but not always associated with diabetes mellitus, chronic …

Dental enamel formation and implications for oral health and disease

RS Lacruz, S Habelitz, JT Wright… - Physiological …, 2017 - journals.physiology.org
Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate
species and provides maximum durability that allows teeth to function as weapons and/or …

Medial vascular calcification revisited: review and perspectives

P Lanzer, M Boehm, V Sorribas, M Thiriet… - European heart …, 2014 - academic.oup.com
Vascular calcifications (VCs) are actively regulated biological processes associated with
crystallization of hydroxyapatite in the extracellular matrix and in cells of the media (VCm) or …

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

X Zhang, D Bogunovic, B Payelle-Brogard… - Nature, 2015 - nature.com
Intracellular ISG15 is an interferon (IFN)-α/β-inducible ubiquitin-like modifier which can
covalently bind other proteins in a process called ISGylation; it is an effector of IFN-α/β …

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease

MG Duperron, MJ Knol, Q Le Grand, TE Evans… - Nature medicine, 2023 - nature.com
Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance
imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia …

Hypoparathyroidism

M Mannstadt, JP Bilezikian, RV Thakker… - Nature Reviews …, 2017 - nature.com
Hypoparathyroidism is a disease characterized by inadequately low circulating
concentrations of parathyroid hormone (PTH) resulting in low calcium levels and increased …

Vascular calcification: key roles of phosphate and pyrophosphate

R Villa-Bellosta - International Journal of Molecular Sciences, 2021 - mdpi.com
Cardiovascular complications due to accelerated arterial stiffening and atherosclerosis are
the leading cause of morbimortality in Western society. Both pathologies are frequently …

N omenclature of genetic movement disorders: R ecommendations of the international P arkinson and movement disorder society task force

C Marras, A Lang, BP van de Warrenburg… - Movement …, 2016 - Wiley Online Library
The system of assigning locus symbols to specify chromosomal regions that are associated
with a familial disorder has a number of problems when used as a reference list of …