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Cell therapy: types, regulation, and clinical benefits
Cell therapy practices date back to the 19th century and continue to expand on
investigational and investment grounds. Cell therapy includes stem cell-and non–stem cell …
investigational and investment grounds. Cell therapy includes stem cell-and non–stem cell …
MYC: connecting selective transcriptional control to global RNA production
TR Kress, A Sabò, B Amati - Nature Reviews Cancer, 2015 - nature.com
Two opposing models have been proposed to describe the function of the MYC oncoprotein
in sha** cellular transcriptomes: one posits that MYC amplifies transcription at all active …
in sha** cellular transcriptomes: one posits that MYC amplifies transcription at all active …
[HTML][HTML] Circulating tumor cell clustering shapes DNA methylation to enable metastasis seeding
The ability of circulating tumor cells (CTCs) to form clusters has been linked to increased
metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain …
metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain …
NUSAP1-LDHA-Glycolysis-Lactate feedforward loop promotes Warburg effect and metastasis in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxia and hypovascular
tumor microenvironment. Nucleolar and spindle associated protein 1 (NUSAP1) is a …
tumor microenvironment. Nucleolar and spindle associated protein 1 (NUSAP1) is a …
[HTML][HTML] Histone modifications regulate pioneer transcription factor cooperativity
Pioneer transcription factors have the ability to access DNA in compacted chromatin.
Multiple transcription factors can bind together to a regulatory element in a cooperative way …
Multiple transcription factors can bind together to a regulatory element in a cooperative way …
Cooperative binding of transcription factors orchestrates reprogramming
Summary Oct4, Sox2, Klf4, and cMyc (OSKM) reprogram somatic cells to pluripotency. To
gain a mechanistic understanding of their function, we mapped OSKM-binding, stage …
gain a mechanistic understanding of their function, we mapped OSKM-binding, stage …
[HTML][HTML] Master transcription factors and mediator establish super-enhancers at key cell identity genes
Summary Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and
recruit Mediator to activate much of the gene expression program of pluripotent embryonic …
recruit Mediator to activate much of the gene expression program of pluripotent embryonic …
Single cell RNA-sequencing of pluripotent states unlocks modular transcriptional variation
Embryonic stem cell (ESC) culture conditions are important for maintaining long-term self-
renewal, and they influence cellular pluripotency state. Here, we report single cell RNA …
renewal, and they influence cellular pluripotency state. Here, we report single cell RNA …
The accessible chromatin landscape of the human genome
DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned
the discovery of all classes of cis-regulatory elements including enhancers, promoters …
the discovery of all classes of cis-regulatory elements including enhancers, promoters …
Transcription factor trap** by RNA in gene regulatory elements
Transcription factors (TFs) bind specific sequences in promoter-proximal and-distal DNA
elements to regulate gene transcription. RNA is transcribed from both of these DNA …
elements to regulate gene transcription. RNA is transcribed from both of these DNA …