Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis is a fatal CNS neurodegenerative disease. Despite intensive
research, current management of amyotrophic lateral sclerosis remains suboptimal from …
research, current management of amyotrophic lateral sclerosis remains suboptimal from …
New insights into atypical Alzheimer's disease in the era of biomarkers
Most patients with Alzheimer's disease present with amnestic problems; however, a
substantial proportion, over-represented in young-onset cases, have atypical phenotypes …
substantial proportion, over-represented in young-onset cases, have atypical phenotypes …
Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic …
Background Plasma tau phosphorylated at threonine 217 (p-tau217) and plasma tau
phosphorylated at threonine 181 (p-tau181) are associated with Alzheimer's disease tau …
phosphorylated at threonine 181 (p-tau181) are associated with Alzheimer's disease tau …
Frontotemporal lobar degeneration
Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset
dementia and presents with early social–emotional–behavioural and/or language changes …
dementia and presents with early social–emotional–behavioural and/or language changes …
Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations
Brain clocks, which quantify discrepancies between brain age and chronological age, hold
promise for understanding brain health and disease. However, the impact of diversity …
promise for understanding brain health and disease. However, the impact of diversity …
Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias
Various biomarkers are available to support the diagnosis of neurodegenerative diseases in
clinical and research settings. Among the molecular imaging biomarkers, amyloid-PET …
clinical and research settings. Among the molecular imaging biomarkers, amyloid-PET …
Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration
With the potential development of new disease-modifying Alzheimer's disease (AD)
therapies, simple, widely available screening tests are needed to identify which individuals …
therapies, simple, widely available screening tests are needed to identify which individuals …
National Institute of Neurological Disorders and Stroke consensus diagnostic criteria for traumatic encephalopathy syndrome
Objective To develop evidence-informed, expert consensus research diagnostic criteria for
traumatic encephalopathy syndrome (TES), the clinical disorder associated with …
traumatic encephalopathy syndrome (TES), the clinical disorder associated with …
Neuroinflammation as a common feature of neurodegenerative disorders
L Guzman-Martinez, RB Maccioni, V Andrade… - Frontiers in …, 2019 - frontiersin.org
Neurodegenerative diseases share the fact that they derive from altered proteins that
undergo an unfolding process followed by formation of β-structures and a pathological …
undergo an unfolding process followed by formation of β-structures and a pathological …
Blood biomarkers to detect Alzheimer disease in primary care and secondary care
S Palmqvist, P Tideman, N Mattsson-Carlgren… - JAMA, 2024 - jamanetwork.com
Importance An accurate blood test for Alzheimer disease (AD) could streamline the
diagnostic workup and treatment of AD. Objective To prospectively evaluate a clinically …
diagnostic workup and treatment of AD. Objective To prospectively evaluate a clinically …