Systems approaches have long been used in pharmacology to understand drug action at
the organ and organismal levels. The application of computational and experimental …

Network-based computational biology, with the emphasis on biomolecular interactions and
omics-data integration, has had success in drug development and created new directions …

Transcription factors (TFs) are major trans-acting factors in transcriptional regulation.
Therefore, elucidating TF–target interactions is a key step toward understanding the …

The reconstruction of transcriptional regulatory networks (TRNs) is a long-standing
challenge in human genetics. Numerous computational methods have been developed to …

Transcriptional and post-transcriptional regulation of gene expression is of fundamental
importance to numerous biological processes. Nowadays, an increasing amount of gene …

Transcription factors (TFs) are proteins that bind to specific DNA sequences, thereby playing
crucial roles in gene-expression regulation through controlling the transcription of genetic …

Since its beginning as a data collection more than 20 years ago, the TRANSFAC project
underwent an evolution to become the basis for a complex platform for the description and …

Background Understanding how genes are expressed and regulated in different tissues is a
fundamental and challenging question. However, most of currently available biological …

Transcriptional factors (TFs) and many of their target genes are involved in gene regulation
at the level of transcription. To decipher gene regulatory networks (GRNs) we require a …

Synucleinopathies are neurodegenerative disorders characterized by abnormal α-synuclein
deposition that include Parkinson's disease, dementia with Lewy bodies, and multiple …