The capacity to predict future events permits a creature to detect, model, and manipulate the
causal structure of its interactions with its environment. Behavioral experiments suggest that …

Modern molecular biology has revealed vast numbers of large and complex proteins and
genes that regulate body function. By contrast, discoveries over the past ten years indicate …

How do minds emerge from develo** brains? According to “neural constructivism,” the
representational features of cortex are built from the dynamic interaction between neural …

Since the observation that nitric oxide (NO) can act as an intercellular messenger in the
brain, the past 25 years have witnessed the steady accumulation of evidence that it acts pre …

NO was first characterized in the CNS as the intercellular messenger mediating the increase
in cyclic GMP levels that follows activation of glutamate receptors (Garthwaite et al., 1988) …

Over the last several years, compelling evidence has accumulated indicating that central
hyperactive states resulting from neuronal plastic changes within the spinal cord play a …

There is increasing evidence that nitric oxide (NO), a free radical that can act both as a
signaling molecule and a neurotoxin, is involved in the mechanisms of cerebral ischemia …

Background: Current antipsychotics have only a limited effect on 2 core aspects of
schizophrenia: negative symptoms and cognitive deficits. Minocycline is a second …

Nitric oxide (NO) is undoubtedly quite an important intercellular messenger in cerebral and
peripheral hemodynamics. This molecule, formed by constitutive isomers of NO synthase …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …