Long non-coding RNAs: definitions, functions, challenges and recommendations
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
[HTML][HTML] Long non-coding RNAs: from disease code to drug role
Y Chen, Z Li, X Chen, S Zhang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Enormous studies have corroborated that long non-coding RNAs (lncRNAs) extensively
participate in crucial physiological processes such as metabolism and immunity, and are …
participate in crucial physiological processes such as metabolism and immunity, and are …
NORAD-induced Pumilio phase separation is required for genome stability
Liquid–liquid phase separation is a major mechanism of subcellular compartmentalization,.
Although the segregation of RNA into phase-separated condensates broadly affects RNA …
Although the segregation of RNA into phase-separated condensates broadly affects RNA …
Long noncoding RNAs: molecular modalities to organismal functions
We have known for decades that long noncoding RNAs (lncRNAs) can play essential
functions across most forms of life. The maintenance of chromosome length requires an …
functions across most forms of life. The maintenance of chromosome length requires an …
Small and long non-coding RNAs: Past, present, and future
LL Chen, VN Kim - Cell, 2024 - cell.com
Since the introduction of the central dogma of molecular biology in 1958, various RNA
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo
Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA
(lncRNA) loci in the human genome, but evidence of functional significance has remained …
(lncRNA) loci in the human genome, but evidence of functional significance has remained …
Mitochondrial dysfunction in Parkinson's disease: from mechanistic insights to therapy
XY Gao, T Yang, Y Gu, XH Sun - Frontiers in aging neuroscience, 2022 - frontiersin.org
Parkinson's disease (PD) is one of the most common neurodegenerative movement
disorders worldwide. There are currently no cures or preventative treatments for PD …
disorders worldwide. There are currently no cures or preventative treatments for PD …
A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence
Cellular senescence is an irreversible state of cell-cycle arrest induced by various stresses,
including aberrant oncogene activation, telomere shortening, and DNA damage. Through a …
including aberrant oncogene activation, telomere shortening, and DNA damage. Through a …
WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration
G Li, L Ma, S He, R Luo, B Wang, W Zhang… - Nature …, 2022 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent RNA modification at the
posttranscriptional level and involved in various diseases and cellular processes. However …
posttranscriptional level and involved in various diseases and cellular processes. However …