The kinetochore
IM Cheeseman - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …
cells. The central player in this process is the macromolecular kinetochore structure, which …
The cell cycle, cancer development and therapy
E Jamasbi, M Hamelian, MA Hossain… - Molecular biology reports, 2022 - Springer
The process of cell division plays a vital role in cancer progression. Cell proliferation and
error-free chromosomes segregation during mitosis are central events in life cycle. Mistakes …
error-free chromosomes segregation during mitosis are central events in life cycle. Mistakes …
Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes
Accurate chromosome segregation requires assembly of the multiprotein kinetochore
complex at centromeres. Although prior work identified the centromeric histone H3-variant …
complex at centromeres. Although prior work identified the centromeric histone H3-variant …
Structural and functional organization of the Ska complex, a key component of the kinetochore-microtubule interface
AA Jeyaprakash, A Santamaria, U Jayachandran… - Molecular cell, 2012 - cell.com
The Ska complex is an essential mitotic component required for accurate cell division in
human cells. It is composed of three subunits that function together to establish stable …
human cells. It is composed of three subunits that function together to establish stable …
[HTML][HTML] Mislocalization of centromeric histone H3 variant CENP-A contributes to chromosomal instability (CIN) in human cells
Chromosomal instability (CIN) is a hallmark of many cancers and a major contributor to
tumorigenesis. Centromere and kinetochore associated proteins such as the evolutionarily …
tumorigenesis. Centromere and kinetochore associated proteins such as the evolutionarily …
Orchestration of the spindle assembly checkpoint by CDK1‐cyclin B1
In mitosis, the spindle assembly checkpoint (SAC) monitors the formation of microtubule‐
kinetochore attachments during capture of chromosomes by the mitotic spindle. Spindle …
kinetochore attachments during capture of chromosomes by the mitotic spindle. Spindle …
Chromosomes trapped in micronuclei are liable to segregation errors
ABSTRACT DNA in micronuclei is likely to get damaged. When shattered DNA from
micronuclei gets reincorporated into the primary nucleus, aberrant rearrangements can take …
micronuclei gets reincorporated into the primary nucleus, aberrant rearrangements can take …
Kinetochore assembly throughout the cell cycle
AP Navarro, IM Cheeseman - Seminars in cell & developmental biology, 2021 - Elsevier
The kinetochore plays an essential role in facilitating chromosome segregation during cell
division. This massive protein complex assembles onto the centromere of chromosomes and …
division. This massive protein complex assembles onto the centromere of chromosomes and …
The KMN protein network–chief conductors of the kinetochore orchestra
D Varma, ED Salmon - Journal of cell science, 2012 - journals.biologists.com
Successful completion of mitosis requires that sister kinetochores become attached end-on
to the plus ends of spindle microtubules (MTs) in prometaphase, thereby forming …
to the plus ends of spindle microtubules (MTs) in prometaphase, thereby forming …
CDK-dependent phosphorylation and nuclear exclusion coordinately control kinetochore assembly state
Accurate chromosome segregation requires assembly of the multiprotein kinetochore
complex. Prior work has identified more than 100 different kinetochore components in …
complex. Prior work has identified more than 100 different kinetochore components in …