[HTML][HTML] The effect of oxidative stress-induced autophagy by cadmium exposure in kidney, liver, and bone damage, and neurotoxicity

Y Ma, Q Su, C Yue, H Zou, J Zhu, H Zhao… - International Journal of …, 2022 - mdpi.com
Environmental and occupational exposure to cadmium has been shown to induce kidney
damage, liver injury, neurodegenerative disease, and osteoporosis. However, the …

Pathogenic mechanisms of glucocorticoid-induced osteoporosis

M Chen, W Fu, H Xu, C Liu - Cytokine & growth factor reviews, 2023 - Elsevier
Glucocorticoid (GC) is one of the most prescribed medicines to treat various inflammatory
and autoimmune diseases. However, high doses and long-term use of GCs lead to multiple …

[HTML][HTML] Irisin as an agent for protecting against osteoporosis: A review of the current mechanisms and pathways

X Hu, Z Wang, W Wang, P Cui, C Kong, X Chen… - Journal of Advanced …, 2024 - Elsevier
Background Osteoporosis is recognized as a skeletal disorder characterized by diminished
bone tissue quality and density. Regular physical exercise is widely acknowledged to …

Exercise for osteoarthritis: a literature review of pathology and mechanism

H Kong, XQ Wang, XA Zhang - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Osteoarthritis (OA) has a very high incidence worldwide and has become a very common
joint disease in the elderly. Currently, the treatment methods for OA include surgery, drug …

[HTML][HTML] Targeting proteostasis network in osteoporosis: pathological mechanisms and therapeutic implications

C Ma, R Yu, J Li, J Chao, P Liu - Ageing research reviews, 2023 - Elsevier
As the most common bone disease, osteoporosis (OP) increases bone fragility and makes
patients more vulnerable to the threat of osteoporotic fractures. With the ageing population in …

Graphene: a multifaceted carbon-based material for bone tissue engineering applications

D Govindarajan, S Saravanan, S Sudhakar… - ACS …, 2023 - ACS Publications
Tissue engineering is an emerging technological field that aims to restore and replace
human tissues. A significant number of individuals require bone replacement annually as a …

[HTML][HTML] Neuroinflammation and autophagy in Parkinson's disease—novel perspectives

D Minchev, M Kazakova, V Sarafian - International Journal of Molecular …, 2022 - mdpi.com
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. It is
characterized by the accumulation of α-Synuclein aggregates and the degeneration of …

Osteoclasts and osteoarthritis: novel intervention targets and therapeutic potentials during aging

H Wang, T Yuan, Y Wang, C Liu, D Li, Z Li, S Sun - Aging Cell, 2024 - Wiley Online Library
Osteoarthritis (OA), a chronic degenerative joint disease, is highly prevalent among the
aging population, and often leads to joint pain, disability, and a diminished quality of life …

Bone cells and their role in physiological remodeling

GBM Maciel, RM Maciel, CC Danesi - Molecular Biology Reports, 2023 - Springer
Purpose: This work compiles the characteristics of bone cells involved in the physiological
bone remodeling. Methods: A narrative review of the literature was performed. Results …

Bioactive silica nanoparticles target autophagy, NF-κB, and MAPK pathways to inhibit osteoclastogenesis

J Arnst, Z **g, C Cohen, SW Ha, M Viggeswarapu… - Biomaterials, 2023 - Elsevier
Spherical 50 nm silica-based nanoparticles (SiNPs) promote healthy bone homeostasis and
maintenance by supporting bone forming osteoblast lineage cells while simultaneously …