Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19
A Bonaventura, A Vecchié, L Dagna… - Nature Reviews …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …
Severe covid-19 pneumonia: pathogenesis and clinical management
Severe covid-19 pneumonia has posed critical challenges for the research and medical
communities. Older age, male sex, and comorbidities increase the risk for severe disease …
communities. Older age, male sex, and comorbidities increase the risk for severe disease …
Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia
Some patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
develop severe pneumonia and acute respiratory distress syndrome (ARDS). Distinct …
develop severe pneumonia and acute respiratory distress syndrome (ARDS). Distinct …
Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study
Background Patients with COVID-19 can develop acute respiratory distress syndrome
(ARDS), which is associated with high mortality. The aim of this study was to examine the …
(ARDS), which is associated with high mortality. The aim of this study was to examine the …
The pathophysiology of 'happy'hypoxemia in COVID-19
S Dhont, E Derom, E Van Braeckel, P Depuydt… - Respiratory …, 2020 - Springer
The novel coronavirus disease 2019 (COVID-19) pandemic is a global crisis, challenging
healthcare systems worldwide. Many patients present with a remarkable disconnect in rest …
healthcare systems worldwide. Many patients present with a remarkable disconnect in rest …
Characterization of the inflammatory response to severe COVID-19 illness
OJ McElvaney, NL McEvoy, OF McElvaney… - American journal of …, 2020 - atsjournals.org
Rationale: Coronavirus disease (COVID-19) is a global threat to health. Its inflammatory
characteristics are incompletely understood. Objectives: To define the cytokine profile of …
characteristics are incompletely understood. Objectives: To define the cytokine profile of …
Organ-specific manifestations of COVID-19 infection
Although COVID-19 presents primarily as a lower respiratory tract infection transmitted via
air droplets, increasing data suggest multiorgan involvement in patients that are infected …
air droplets, increasing data suggest multiorgan involvement in patients that are infected …
[HTML][HTML] Large-scale multi-omic analysis of COVID-19 severity
We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …
[HTML][HTML] COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted?
E Fan, JR Beitler, L Brochard, CS Calfee… - The Lancet …, 2020 - thelancet.com
The COVID-19 pandemic has seen a surge of patients with acute respiratory distress
syndrome (ARDS) in intensive care units across the globe. As experience of managing …
syndrome (ARDS) in intensive care units across the globe. As experience of managing …
Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS
C Ferrando, F Suarez-Sipmann, R Mellado-Artigas… - Intensive care …, 2020 - Springer
Purpose The main characteristics of mechanically ventilated ARDS patients affected with
COVID-19, and the adherence to lung-protective ventilation strategies are not well known …
COVID-19, and the adherence to lung-protective ventilation strategies are not well known …