[HTML][HTML] Structure and function meet at the nicotinic acetylcholine receptor-lipid interface
FJ Barrantes - Pharmacological Research, 2023 - Elsevier
The nicotinic acetylcholine receptor (nAChR) is a transmembrane protein that mediates fast
intercellular communication in response to the endogenous neurotransmitter acetylcholine …
intercellular communication in response to the endogenous neurotransmitter acetylcholine …
Discovery of therapeutic antibodies targeting complex multi-spanning membrane proteins
AD Stephens, T Wilkinson - BioDrugs, 2024 - Springer
Complex integral membrane proteins, which are embedded in the cell surface lipid bilayer
by multiple transmembrane spanning polypeptides, encompass families of proteins that are …
by multiple transmembrane spanning polypeptides, encompass families of proteins that are …
[HTML][HTML] Structure and dynamics of differential ligand binding in the human ρ-type GABAA receptor
The neurotransmitter γ-aminobutyric acid (GABA) drives critical inhibitory processes in and
beyond the nervous system, partly via ionotropic type-A receptors (GABA A Rs) …
beyond the nervous system, partly via ionotropic type-A receptors (GABA A Rs) …
[HTML][HTML] Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation
The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel that plays
an important role in cholinergic signaling throughout the nervous system. Its unique …
an important role in cholinergic signaling throughout the nervous system. Its unique …
Influence of lipid bilayer on the structure of the muscle-type nicotinic acetylcholine receptor
N Unwin - Proceedings of the National Academy of …, 2024 - National Acad Sciences
The muscle-type nicotinic acetylcholine receptor is a transmitter-gated ion channel residing
in the plasma membrane of electrocytes and striated muscle cells. It is present …
in the plasma membrane of electrocytes and striated muscle cells. It is present …
Mechanisms underlying modulation of human GlyRα3 by Zn2+ and pH
Glycine receptors (GlyRs) regulate motor control and pain processing in the central nervous
system through inhibitory synaptic signaling. The subtype GlyRα3 expressed in nociceptive …
system through inhibitory synaptic signaling. The subtype GlyRα3 expressed in nociceptive …
Divergent mechanisms of steroid inhibition in the human ρ1 GABAA receptor
Abstract ρ-type γ-aminobutyric acid-A (GABAA) receptors are widely distributed in the retina
and brain, and are potential drug targets for the treatment of visual, sleep and cognitive …
and brain, and are potential drug targets for the treatment of visual, sleep and cognitive …
Resolving native GABAA receptor structures from the human brain
Type A GABA (γ-aminobutyric acid) receptors (GABAA receptors) mediate most fast
inhibitory signalling in the brain and are targets for drugs that treat epilepsy, anxiety …
inhibitory signalling in the brain and are targets for drugs that treat epilepsy, anxiety …
Cryo-EM structure of the zinc-activated channel (ZAC) in the Cys-loop receptor superfamily
F **, YY Lin, RC Wang, TX **e, Y Zhao, C Shen… - Proceedings of the …, 2024 - pnas.org
Cys-loop receptors are a large superfamily of pentameric ligand-gated ion channels with
various physiological roles, especially in neurotransmission in the central nervous system …
various physiological roles, especially in neurotransmission in the central nervous system …
Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment
GLIC, a proton-activated prokaryotic ligand-gated ion channel, served as a model system for
understanding the eukaryotic counterparts due to their structural and functional similarities …
understanding the eukaryotic counterparts due to their structural and functional similarities …