Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules
that are found in a wide range of proteins with diverse catalytic and scaffolding functions and …

Chromatin immunoprecipitation experiments followed by sequencing (ChIP–seq) detect
protein–DNA binding events and chemical modifications of histone proteins. Challenges in …

Chromatin features are widely used for genome-scale map** of enhancers. However,
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …

The acetyltransferases CBP and p300 are multifunctional transcriptional co-activators. Here,
we combined quantitative proteomics with CBP/p300-specific catalytic inhibitors …

A few scientists who have been burned by bad experiences with antibodies have begun to
speak up. Rimm's disappointment set him on a crusade to educate others by writing reviews …

Chromatin immunoprecipitation (ChIP) followed by high-throughput DNA sequencing (ChIP-
seq) has become a valuable and widely used approach for map** the genomic location of …

Histones function both positively and negatively in the regulation of gene expression, mainly
governed by post-translational modifications on specific amino acid residues. Although …

Protein lysine methylation is a distinct posttranslational modification that causes minimal
changes in the size and electrostatic status of lysine residues. Lysine methylation plays …

The ability to form memories is a prerequisite for an organism's behavioral adaptation to
environmental changes. At the molecular level, the acquisition and maintenance of memory …

Post-translational modifications (PTMs) provide a rapid response to stimuli, finely tuning
metabolism and gene expression and maintain homeostasis. Advances in mass …