[HTML][HTML] Stress, epigenetics, and aging: unraveling the intricate crosstalk
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
Methyltransferase-like proteins in cancer biology and potential therapeutic targeting
YN Qi, Z Liu, LL Hong, P Li, ZQ Ling - Journal of hematology & oncology, 2023 - Springer
RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 …
Q Li, Y Ni, L Zhang, R Jiang, J Xu, H Yang… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in
human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy …
human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy …
METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis
METTL16 has recently been identified as an RNA methyltransferase responsible for the
deposition of N 6-methyladenosine (m6A) in a few transcripts. Whether METTL16 methylates …
deposition of N 6-methyladenosine (m6A) in a few transcripts. Whether METTL16 methylates …
KAT8-catalyzed lactylation promotes eEF1A2-mediated protein synthesis and colorectal carcinogenesis
B **e, M Zhang, J Li, J Cui, P Zhang, F Liu… - Proceedings of the …, 2024 - pnas.org
Aberrant lysine lactylation (Kla) is associated with various diseases which are caused by
excessive glycolysis metabolism. However, the regulatory molecules and downstream …
excessive glycolysis metabolism. However, the regulatory molecules and downstream …
N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression
Z Dai, H Liu, J Liao, C Huang, X Ren, W Zhu, S Zhu… - Molecular cell, 2021 - cell.com
Cancer cells selectively promote translation of specific oncogenic transcripts to facilitate
cancer survival and progression, but the underlying mechanisms are poorly understood …
cancer survival and progression, but the underlying mechanisms are poorly understood …
The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation
T Liu, Q Wei, J **, Q Luo, Y Liu, Y Yang… - Nucleic acids …, 2020 - academic.oup.com
Abstract N 6-Methyladenosine (m6A) is the most abundant RNA modification in mammal
mRNAs and increasing evidence suggests the key roles of m6A in human tumorigenesis …
mRNAs and increasing evidence suggests the key roles of m6A in human tumorigenesis …
Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
L Fang, Y Hao, H Yu, X Gu, Q Peng, H Zhuo, Y Li, Z Liu… - Cancer Cell, 2023 - cell.com
Summary Cyclic GMP-AMP synthase (cGAS) is the major sensor for cytosolic DNA and
activates type I interferon signaling and plays an essential role in antitumor immunity …
activates type I interferon signaling and plays an essential role in antitumor immunity …
[HTML][HTML] High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate
P Zhou, W Chang, D Gong, J **a, W Chen, L Huang… - Cell Metabolism, 2023 - cell.com
Emerging studies have addressed the tumor-promoting role of fructose in different cancers.
The effects and pathological mechanisms of high dietary fructose on hepatocellular …
The effects and pathological mechanisms of high dietary fructose on hepatocellular …
[HTML][HTML] mRNA decoding in human is kinetically and structurally distinct from bacteria
In all species, ribosomes synthesize proteins by faithfully decoding messenger RNA (mRNA)
nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the …
nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the …