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Genetics and pathogenesis of Parkinson's syndrome
Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …
Natural antisense transcripts as versatile regulators of gene expression
Long non-coding RNAs (lncRNAs) are emerging as a major class of gene products that
have central roles in cell and developmental biology. Natural antisense transcripts (NATs) …
have central roles in cell and developmental biology. Natural antisense transcripts (NATs) …
Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation
XY **, AG Hirsch, S Wasilewski… - Nature, 2024 - nature.com
When mRNAs have been transcribed and processed in the nucleus, they are exported to the
cytoplasm for translation. This export is mediated by the export receptor heterodimer Mex67 …
cytoplasm for translation. This export is mediated by the export receptor heterodimer Mex67 …
Unraveling the complex role of MAPT-containing H1 and H2 haplotypes in neurodegenerative diseases
A~ 1 Mb inversion polymorphism exists within the 17q21. 31 locus of the human genome as
direct (H1) and inverted (H2) haplotype clades. This inversion region demonstrates high …
direct (H1) and inverted (H2) haplotype clades. This inversion region demonstrates high …