Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Potential of cyanine derived dyes in photodynamic therapy

N Lange, W Szlasa, J Saczko, A Chwiłkowska - Pharmaceutics, 2021 - mdpi.com
Photodynamic therapy (PDT) is a method of cancer treatment that leads to the disintegration
of cancer cells and has developed significantly in recent years. The clinically used …

An approach to develo** cyanines with simultaneous intersystem crossing enhancement and excited-state lifetime elongation for photodynamic antitumor …

X Zhao, Q Yao, S Long, W Chi, Y Yang… - Journal of the …, 2021 - ACS Publications
Heavy-atom-based photosensitizers usually exhibit shortened triplet-state lifetimes, which is
not ideal for hypoxic tumor photodynamic therapy. Although several heavy-atom-free …

Single-atom engineering of hemicyanine and its amphiphilic derivative for optimized near infrared phototheranostics

S Yao, Y Chen, W Ding, F Xu, Z Liu, Y Li, Y Wu, S Li… - Chemical …, 2023 - pubs.rsc.org
Near-infrared (NIR) dyes are widely used in the field of in vivo phototheranostics.
Hemicyanine dyes (HDs) have recently received tremendous attention due to their easy …

Photodynamic Therapy: From the Basics to the Current Progress of N-Heterocyclic-Bearing Dyes as Effective Photosensitizers

E Lima, LV Reis - Molecules, 2023 - mdpi.com
Photodynamic therapy, an alternative that has gained weight and popularity compared to
current conventional therapies in the treatment of cancer, is a minimally invasive therapeutic …

Recent advances in cyanine-based phototherapy agents

K Bilici, S Cetin, E Celikbas, H Yagci Acar… - Frontiers in …, 2021 - frontiersin.org
Phototherapies, in the form of photodynamic therapy (PDT) and photothermal therapy (PTT),
are very promising treatment modalities for cancer since they provide locality and turn-on …

Deciphering the structure–property relations in substituted heptamethine cyanines

L Stackova, E Muchova, M Russo… - The Journal of …, 2020 - ACS Publications
Heptamethine cyanines (Cy7) are fluorophores essential for modern bioimaging techniques
and chemistry. Here, we systematically evaluated the photochemical and photophysical …

Three birds with one stone: acceptor engineering of hemicyanine dye with NIR‐II emission for synergistic photodynamic and photothermal anticancer therapy

W Cao, Y Zhu, F Wu, Y Tian, Z Chen, W Xu, S Liu, T Liu… - Small, 2022 - Wiley Online Library
It is challenging to develop a near‐infrared (NIR) small molecular photosensitizer for
synergistic phototherapy in deep tissues. Herein, first, a heavy‐atom‐free NIR hemicyanine …

NIR‐II cyanine@ albumin fluorophore for deep tissue imaging and imaging‐guided surgery

Y Zhang, Y Jia, S Zhu - SmartMat, 2024 - Wiley Online Library
Abstract The near‐infrared (NIR)‐II bioimaging technique is highly important for both
diagnosing and treating life‐threatening diseases due to its exceptional imaging …

Explorations into the Effect of meso‐Substituents in Tricarbocyanine Dyes: A Path to Diverse Biomolecular Probes and Materials

RM Exner, F Cortezon‐Tamarit… - Angewandte Chemie …, 2021 - Wiley Online Library
Polymethine cyanine dyes have been widely recognized as promising chemical tools for a
range of life science and biomedical applications, such as fluorescent staining of DNA and …