Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer
A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …
The regulation of PBXs and their emerging role in cancer
Y Liu, X Ao, X Zhou, C Du… - Journal of Cellular and …, 2022 - Wiley Online Library
Pre‐B‐cell leukaemia transcription factor (PBX) proteins are a subfamily of evolutionarily
conserved, atypical homeodomain transcription factors that belong to the superfamily of …
conserved, atypical homeodomain transcription factors that belong to the superfamily of …
Co-targeting autophagy and NRF2 signaling triggers mitochondrial superoxide to sensitize oral cancer stem cells for cisplatin-induced apoptosis
Cancer stem cell (CSC) populations are regulated by autophagy, which in turn modulates
tumorigenicity and malignancy. In this study, we demonstrated that cisplatin treatment …
tumorigenicity and malignancy. In this study, we demonstrated that cisplatin treatment …
SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway
SIRT1 (NAD-dependent protein deacetylase sirtuin-1), a class III histone deacetylase acting
as a tumor suppressor gene, is downregulated in oral cancer cells. Non-apoptotic doses of …
as a tumor suppressor gene, is downregulated in oral cancer cells. Non-apoptotic doses of …
New insights into mitophagy and stem cells
Q Lin, J Chen, L Gu, X Dan, C Zhang… - Stem cell research & …, 2021 - Springer
Mitophagy is a specific autophagic phenomenon in which damaged or redundant
mitochondria are selectively cleared by autophagic lysosomes. A decrease in mitophagy …
mitochondria are selectively cleared by autophagic lysosomes. A decrease in mitophagy …
Cancer stem cell fate determination: mito-nuclear communication
M Fan, Y Shi, J Zhao, L Li - Cell Communication and Signaling, 2023 - Springer
Cancer stem cells (CSCs) are considered to be responsible for tumor recurrence and
metastasis. Therefore, clarification of the mechanisms involved in CSC stemness …
metastasis. Therefore, clarification of the mechanisms involved in CSC stemness …
Targeting autophagy and lipid metabolism in cancer stem cells
Cancer stem cells (CSCs) are a subset of cancer cells with self-renewal ability and tumor
initiating properties. Unlike the other non-stem cancer cells, CSCs resist traditional therapy …
initiating properties. Unlike the other non-stem cancer cells, CSCs resist traditional therapy …
The multifaceted roles of mitochondria at the crossroads of cell life and death in cancer
F Fontana, P Limonta - Free Radical Biology and Medicine, 2021 - Elsevier
Mitochondria are the cytoplasmic organelles mostly known as the “electric engine” of the
cells; however, they also play pivotal roles in different biological processes, such as cell …
cells; however, they also play pivotal roles in different biological processes, such as cell …
The mitochondrial calcium signaling, regulation, and cellular functions: A novel target for therapeutic medicine in neurological disorders
Abstract Mitochondrial calcium (Ca2+) dynamics play critical roles in regulating vital
physiological conditions in the brain. Importantly, Mitochondria‐associated endoplasmic …
physiological conditions in the brain. Importantly, Mitochondria‐associated endoplasmic …
CLU (clusterin) promotes mitophagic degradation of MSX2 through an AKT-DNM1L/Drp1 axis to maintain SOX2-mediated stemness in oral cancer stem cells
Mitophagy regulates cancer stem cell (CSC) populations affecting tumorigenicity and
malignancy in various cancer types. Here, we report that cisplatin treatment led to the …
malignancy in various cancer types. Here, we report that cisplatin treatment led to the …