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A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen Candida albicans
Candida albicans, one of the most prevalent human fungal pathogens, causes diverse
diseases extending from superficial infections to deadly systemic mycoses. Currently, only …
diseases extending from superficial infections to deadly systemic mycoses. Currently, only …
Leveraging the MMV Pathogen Box to Engineer an Antifungal Compound with Improved Efficacy and Selectivity against Candida auris
Fungal infections pose a significant and increasing threat to human health, but the current
arsenal of antifungal drugs is inadequate. We screened the Medicines for Malaria Venture …
arsenal of antifungal drugs is inadequate. We screened the Medicines for Malaria Venture …
Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans
P Vande Zande, C Gautier, N Kawar, C Maufrais… - PLoS …, 2024 - journals.plos.org
Antimicrobial drug resistance poses a global health threat, requiring a deeper
understanding of the evolutionary processes that lead to its emergence in pathogens …
understanding of the evolutionary processes that lead to its emergence in pathogens …
Evaluating the Impact of Antifungal Drugs on Human Health and Exploring Alternative Treatments.
D MANDAL - Oriental Journal of Chemistry, 2024 - search.ebscohost.com
Fungi occurred naturally like Candida yeast, in the human body. It may grow on skin, inside
the digestive system and vagina. Antifungal drugs are used to kill or stop this fungal growth …
the digestive system and vagina. Antifungal drugs are used to kill or stop this fungal growth …
Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity
Candida species are among the most prevalent causes of systemic fungal infections, which
account for∼ 1.5 million annual fatalities. Here, we build on a compound screen that …
account for∼ 1.5 million annual fatalities. Here, we build on a compound screen that …