Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …

The first bacterial genome was sequenced in 1995, and the first archaeal genome in 1996.
Soon after these breakthroughs, an exponential rate of genome sequencing was …

Background Genome-scale prediction of gene regulation and reconstruction of
transcriptional regulatory networks in prokaryotes is one of the critical tasks of modern …

Bacteria often cope with environmental stress by inducing alternative sigma (σ) factors,
which direct RNA polymerase to specific promoters, thereby inducing a set of genes called a …

The Escherichia coli cyclic AMP receptor protein (CRP) is a global regulator that controls
transcription initiation from more than 100 promoters by binding to a specific DNA sequence …

Identifying genomic locations of transcription-factor binding sites, particularly in higher
eukaryotic genomes, has been an enormous challenge. Various experimental and …

The vast majority of experimental data have been accumulated on the transcription
regulation of individual genes within a single model prokaryote, Escherichia coli, which form …

FNR is a well-studied global regulator of anaerobiosis, which is widely conserved across
bacteria. Despite the importance of FNR and anaerobiosis in microbial lifestyles, the factors …

Chromatin immunoprecipitation and high-density microarrays have been used to monitor the
distribution of the global transcription regulator Escherichia coli cAMP-receptor protein …

While the molecular mechanisms of glucocorticoid regulation of transcription have been
studied in detail, the global networks regulated by the glucocorticoid receptor (GR) remain …