Despite the intuitive value of adopting the Findable, Accessible, Interoperable, and
Reusable (FAIR) principles in both academic and industrial sectors, challenges exist in …

Over the last 40 years, evidence-based practices and methods have revolutionized the
practice of medicine, improved the standards of basic clinical research, and led to the broad …

Findings from animal experiments are often difficult to transfer to humans. In this perspective
article I discuss two questions. First, why are the results of animal experiments often so …

In silico predictive models for toxicology include quantitative structure-activity relationship
(QSAR) and physiologically based kinetic (PBK) approaches to predict physico-chemical …

Four decades of the Human Genome Project and its consequences have shown how the
entrepreneurial state, through significant investment into science, can drive scientific …

The management and protection of data-based intellectual property have attracted
increasing attention in the academic community due to the rapid development of digital …

A physiologically-based pharmacokinetic (PBPK) model represents the structural
components of the body with physiologically relevant compartments connected via blood …

Over the last few decades the pharmaceutical industry has generated a vast corpus of
knowledge on the safety and efficacy of drugs. Much of this information is contained in …

The present contribution describes how in silico models and methods are applied at different
stages of the drug discovery process in the pharmaceutical industry. A description of the …

Decades of research on environmental, health and safety impacts of nanomaterials have
generated large amounts of nanosafety data, but not all data are available online following …