Permeation of the cell membrane leading to cell death is a mechanism used by a large
number of membrane-lytic peptides. Some are linear, mostly helical, and others contain one …

The increasing resistance of bacteria to conventional antibiotics resulted in a strong effort to
develop antimicrobial compounds with new mechanisms of action. Antimicrobial peptides …

In many branches of materials science it is now routine to generate data sets of such large
size and dimensionality that conventional methods of analysis fail. Paradigms and tools from …

The argument and experimental evidence are presented for a two-state model that explains
the action of both helical and β-sheet antimicrobial peptides after they bind to the plasma …

Magainins are a class of antimicrobial peptides discovered in the skin of Xenopus laevis.
The peptides kill bacteria by permeabilizing the cell membranes without exhibiting …

Linear peptide antibiotics have been isolated from amphibians, insects and humans and
used as templates to design cheaper and more potent analogues for medical applications …

Based on very extensive studies on four peptides (alamethicin, melittin, magainin and
protegrin), we propose a mechanism to explain the cooperativity exhibited by the activities of …

The structure and functions of membrane-active peptides are extensively reviewed. These
peptides including cecropins from insects, melittin from honey bees (Apis mellifera) and …

Magainin 2 is a 23‐residue peptide that forms an amphipathic α‐helix in membrane
environments. It functions as an antibiotic and is known to disrupt the electrochemical …

Cecropins are positively charged antibacterial peptides that act by permeating the
membrane of susceptible bacteria. To gain insight into the mechanism of membrane …