Glucocorticoids in T cell development, differentiation and function

MD Taves, JD Ashwell - Nature Reviews Immunology, 2021 - nature.com
Glucocorticoids (GCs) are small lipid hormones produced by the adrenals that maintain
organismal homeostasis. Circadian and stress-induced changes in systemic GC levels …

Targeting cytokines to treat asthma and chronic obstructive pulmonary disease

PJ Barnes - Nature Reviews Immunology, 2018 - nature.com
Cytokines play a key role in orchestrating and perpetuating the chronic airway inflammation
in asthma and chronic obstructive pulmonary disease (COPD), making them attractive …

Glucocorticoids—all-rounders tackling the versatile players of the immune system

C Strehl, L Ehlers, T Gaber, F Buttgereit - Frontiers in immunology, 2019 - frontiersin.org
Glucocorticoids regulate fundamental processes of the human body and control cellular
functions such as cell metabolism, growth, differentiation, and apoptosis. Moreover …

Oxidative stress and inflammation in acute and chronic lung injuries

FS Bezerra, M Lanzetti, RT Nesi, AC Nagato, CP Silva… - Antioxidants, 2023 - mdpi.com
Acute and chronic lung injuries are among the leading causes of mortality worldwide. Lung
injury can affect several components of the respiratory system, including the airways …

New insights into the cell-and tissue-specificity of glucocorticoid actions

L Quatrini, S Ugolini - Cellular & molecular immunology, 2021 - nature.com
Glucocorticoids (GCs) are endogenous hormones that are crucial for the homeostasis of the
organism and adaptation to the external environment. Because of their anti-inflammatory …

Asthma phenotypes: the evolution from clinical to molecular approaches

SE Wenzel - Nature medicine, 2012 - nature.com
Although asthma has been considered as a single disease for years, recent studies have
increasingly focused on its heterogeneity. The characterization of this heterogeneity has …

Mechanisms and functions of p38 MAPK signalling

A Cuadrado, AR Nebreda - Biochemical journal, 2010 - portlandpress.com
The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to
interpret a wide range of external signals and respond appropriately by generating a …

Glucocorticosteroids: current and future directions

PJ Barnes - British journal of pharmacology, 2011 - Wiley Online Library
Glucocorticoids are the most effective anti‐inflammatory therapy for asthma yet are relatively
ineffective in chronic obstructive pulmonary disease. Glucocorticoids suppress inflammation …

Pathophysiology of allergic inflammation

PJ Barnes - Immunological reviews, 2011 - Wiley Online Library
Allergic inflammation is due to a complex interplay between several inflammatory cells,
including mast cells, basophils, lymphocytes, dendritic cells, eosinophils, and sometimes …

Corticosteroids for COVID-19

D Annane - Journal of Intensive Medicine, 2021 - mednexus.org
Coronavirus disease 19 (COVID-19) is placing a major burden on healthcare, economy and
social systems worldwide owing to its fast spread and unacceptably high death toll. The …