Bioinformatic tools for microRNA dissection

MM Akhtar, L Micolucci, MS Islam, F Olivieri… - Nucleic acids …, 2016 - academic.oup.com
Recently, microRNAs (miRNAs) have emerged as important elements of gene regulatory
networks. MiRNAs are endogenous single-stranded non-coding RNAs (∼ 22-nt long) that …

DIANA-miRPath v3. 0: deciphering microRNA function with experimental support

IS Vlachos, K Zagganas… - Nucleic acids …, 2015 - academic.oup.com
The functional characterization of miRNAs is still an open challenge. Here, we present
DIANA-miRPath v3. 0 (http://www. microrna. gr/miRPathv3) an online software suite …

Roles of NF-κB signaling in the regulation of miRNAs impacting on inflammation in cancer

GS Markopoulos, E Roupakia, M Tokamani, G Alabasi… - Biomedicines, 2018 - mdpi.com
The NF-κB family of transcription factors regulate the expression of genes encoding proteins
and microRNAs (miRNA, miR) precursors that may either positively or negatively regulate a …

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

YX Gui, H Liu, LS Zhang, W Lv, XY Hu - Oncotarget, 2015 - pmc.ncbi.nlm.nih.gov
The differential diagnosis of Parkinson's diseases (PD) is challenging, especially in the early
stages of the disease. We developed a microRNA profiling strategy for exosomal miRNAs …

CircOGDH is a penumbra biomarker and therapeutic target in acute ischemic stroke

Y Liu, Y Li, J Zang, T Zhang, Y Li, Z Tan, D Ma… - Circulation …, 2022 - ahajournals.org
Background: Acute ischemic stroke (AIS) is a leading cause of disability and mortality
worldwide. Prediction of penumbra existence after AIS is crucial for making decision on …

DIANA miRPath v. 2.0: investigating the combinatorial effect of microRNAs in pathways

IS Vlachos, N Kostoulas, T Vergoulis… - Nucleic acids …, 2012 - academic.oup.com
MicroRNAs (miRNAs) are key regulators of diverse biological processes and their functional
analysis has been deemed central in many research pipelines. The new version of DIANA …

Targeting the circulating microRNA signature of obesity

FJ Ortega, JM Mercader, V Catalan… - Clinical …, 2013 - academic.oup.com
BACKGROUND Genomic studies have yielded important insights into the pathogenesis of
obesity. Circulating microRNAs (miRNAs) are valuable biomarkers of systemic diseases and …

MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis

J Cai, H Guan, L Fang, Y Yang, X Zhu, J Yuan… - The Journal of clinical …, 2013 - jci.org
Tumor metastasis involves a series of biological steps during which the tumor cells acquire
the ability to invade surrounding tissues and survive outside the original tumor site. During …

Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle

S Nielsen, C Scheele, C Yfanti… - The Journal of …, 2010 - Wiley Online Library
Muscle specific miRNAs, myomiRs, have been shown to control muscle development in vitro
and are differentially expressed at rest in diabetic skeletal muscle. Therefore, we …

miRSystem: an integrated system for characterizing enriched functions and pathways of microRNA targets

TP Lu, CY Lee, MH Tsai, YC Chiu, CK Hsiao, LC Lai… - 2012 - journals.plos.org
Background Many prediction tools for microRNA (miRNA) targets have been developed, but
inconsistent predictions were observed across multiple algorithms, which can make further …