Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

Radiotherapy is used in> 50% of patients with cancer, both for curative and palliative
purposes. Radiotherapy uses ionizing radiation to target and kill tumour tissue, but normal …

Importance Glioblastoma is the most lethal primary brain cancer. Clinical outcomes for
glioblastoma remain poor, and new treatments are needed. Objective To investigate …

The NCCN Guidelines for Central Nervous System (CNS) Cancers focus on management of
adult CNS cancers ranging from noninvasive and surgically curable pilocytic astrocytomas …

Isocitrate dehydrogenase (IDH) mutant gliomas are the most common adult, malignant
primary brain tumors diagnosed in patients younger than 50, constituting an important cause …

This review describes the definition, incidence, clinical implications, and magnetic
resonance imaging (MRI) findings of pseudoprogression of brain tumors, in particular, but …

Human interleukin-12 (hIL-12) is a cytokine with anticancer activity, but its systemic
application is limited by toxic inflammatory responses. We assessed the safety and …

Background Current treatments for recurrent glioblastoma offer limited benefit. The authors
report the antitumor activity and safety of the anti–programmed death 1 (anti–PD‐1) …

MR elastography allows non-invasive quantification of the shear modulus of tissue, ie tissue
stiffness and viscosity, information that offers the potential to guide presurgical planning for …

Cancer immunotherapy has made remarkable advances with over 50 separate Food and
Drug Administration (FDA) approvals as first-or second-line indications since 2015. These …