Hyaluronic acid-based prodrug nanomedicines for enhanced tumor targeting and therapy: A review

R Zhang, X Zhao, A Jia, C Wang, H Jiang - International Journal of …, 2023 - Elsevier
Hyaluronic acid (HA) represents a natural polysaccharide which has attracted significant
attention owing to its improved tumor targeting capacity, enzyme degradation capacity, and …

Hyaluronic acid-empowered nanotheranostics in breast and lung cancers therapy

F Alsaikhan - Environmental Research, 2023 - Elsevier
Nanomedicine application in cancer therapy is an urgency because of inability of current
biological therapies for complete removal of tumor cells. The development of smart and …

Engineering dynamic covalent bond-based nanosystems for delivery of antimicrobials against bacterial infections

A Tageldin, CA Omolo, VO Nyandoro… - Journal of Controlled …, 2024 - Elsevier
Nanodrug delivery systems (NDDS) continue to be explored as novel strategies enhance
therapy outcomes and combat microbial resistance. The need for the formulation of smart …

Hyaluronic acid-silybin conjugate for the preparation of multifunctional, biomimetic, vancomycin-loaded self-assembled polymersomes against bacterial sepsis

MA Gafar, CA Omolo, UH Ibrahim, G Elamin… - International Journal of …, 2025 - Elsevier
Sepsis, a life-threatening disruption, remains a significant global healthcare challenge that
urgently needs novel strategies to improve management. This study aimed to develop …

Multi-functional pH-responsive and biomimetic chitosan-based nanoplexes for targeted delivery of ciprofloxacin against bacterial sepsis

EA Ismail, CA Omolo, MA Gafar, R Khan… - International Journal of …, 2024 - Elsevier
Bacterial sepsis is a mortal syndromic disease characterized by a complex pathophysiology
that hinders effective targeted therapy. This study aimed to develop multifunctional …

Computational, microscale thermophoresis and electrochemical study of a hepta-peptide for a simple, sensitive electrochemical biosensor for PSA

J Alake, MC Mahlalela, S Mohite, S Partap… - Microchemical …, 2024 - Elsevier
Studies indicate a potential 108% increase in incidence and 112% in mortality rate of
prostate cancer in Sub-Saharan Africa by 2040. Electrochemical sensors show promise as …

Niosomes modified with a novel pH-responsive coating (mPEG-OA) enhance the antibacterial and anti-biofilm activity of vancomycin against methicillin-resistant …

N Osman, CA Omolo, MA Gafar, N Devnarain… - Nano …, 2024 - iopscience.iop.org
Surface functionalization of nanoparticles has shown potential in enhancing the efficacy of
antibiotic-loaded nanosystems against drug-resistant bacteria. The objective of this study …

Assessing the efficacy of iso-mukaadial acetate and betulinic acid against selected Plasmodium falciparum glycolytic pathway proteins: in silico and in vitro studies

LK Zuma, OJ Pooe, NH Mabaso, J Alake, VA Obakachi… - BMC chemistry, 2025 - Springer
Malaria is the extensive health concern in sub-Saharan Africa, with Plasmodium falciparum
being the most lethal strain. The continued emergence of drug-resistant P. falciparum …