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CRISPR technology: A decade of genome editing is only the beginning
The advent of clustered regularly interspaced short palindromic repeat (CRISPR) genome
editing, coupled with advances in computing and imaging capabilities, has initiated a new …
editing, coupled with advances in computing and imaging capabilities, has initiated a new …
Importance of the pig as a human biomedical model
Pigs have substantial potential as biomedical models for studying human developmental
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …
Design and testing of a humanized porcine donor for xenotransplantation
Recent human decedent model studies, and compassionate xenograft use have explored
the promise of porcine organs for human transplantation. To proceed to human studies, a …
the promise of porcine organs for human transplantation. To proceed to human studies, a …
First clinical‐grade porcine kidney xenotransplant using a human decedent model
A radical solution is needed for the organ supply crisis, and the domestic pig is a promising
organ source. In preparation for a clinical trial of xenotransplantation, we developed an in …
organ source. In preparation for a clinical trial of xenotransplantation, we developed an in …
CRISPR-Cas guides the future of genetic engineering
The diversity, modularity, and efficacy of CRISPR-Cas systems are driving a
biotechnological revolution. RNA-guided Cas enzymes have been adopted as tools to …
biotechnological revolution. RNA-guided Cas enzymes have been adopted as tools to …
Progress in xenotransplantation: overcoming immune barriers
M Sykes, DH Sachs - Nature Reviews Nephrology, 2022 - nature.com
A major limitation of organ allotransplantation is the insufficient supply of donor organs.
Consequently, thousands of patients die every year while waiting for a transplant. Progress …
Consequently, thousands of patients die every year while waiting for a transplant. Progress …
Ten things you should know about transposable elements
Transposable elements (TEs) are major components of eukaryotic genomes. However, the
extent of their impact on genome evolution, function, and disease remain a matter of intense …
extent of their impact on genome evolution, function, and disease remain a matter of intense …
Gene therapy clinical trials worldwide to 2017: An update
To date, almost 2600 gene therapy clinical trials have been completed, are ongoing or have
been approved worldwide. Our database brings together global information on gene therapy …
been approved worldwide. Our database brings together global information on gene therapy …
[HTML][HTML] CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy
Y Xu, Z Li - Computational and structural biotechnology journal, 2020 - Elsevier
Genome editing is the modification of genomic DNA at a specific target site in a wide variety
of cell types and organisms, including insertion, deletion and replacement of DNA, resulting …
of cell types and organisms, including insertion, deletion and replacement of DNA, resulting …
Vascular tissue engineering: progress, challenges, and clinical promise
Although the clinical demand for bioengineered blood vessels continues to rise, current
options for vascular conduits remain limited. The synergistic combination of emerging …
options for vascular conduits remain limited. The synergistic combination of emerging …