Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane,
where its assembly into cage-like lattices underlies the clathrin-coated pits of classical …

▪ Abstract Dynamin, a 100-kDa GTPase, is an essential component of vesicle formation in
receptor-mediated endocytosis, synaptic vesicle recycling, caveolae internalization, and …

Tau pathology propagates within synaptically connected neuronal circuits, but the
underlying mechanisms are unclear. BIN1-amphiphysin2 is the second most prevalent …

A specific group of transmembrane receptors, including the β1-adrenergic receptor (β1-AR),
is internalized through a non-clathrin pathway known as Fast Endophilin Mediated …

Synaptic vesicles have been proposed to form through two mechanisms: one directly from
the plasma membrane involving clathrin-dependent endocytosis and the adaptor protein …

Cbl is a multi-adaptor protein involved in ligand-induced downregulation of receptor tyrosine
kinases. It is thought that Cbl-mediated ubiquitination of active receptors is essential for …

Ligand-dependent downregulation of tyrosine kinase receptors is a critical step for
modulating their activity. Upon ligand binding, hepatocyte growth factor (HGF) receptor (Met) …

The process by which clathrin-coated vesicles are produced involves interactions of
multifunctional adaptor proteins with the plasma membrane, as well as with clathrin and …

Aggregation of misfolded microtubule associated protein tau into abnormal intracellular
inclusions defines a class of neurodegenerative diseases known as tauopathies. The …

Endophilin is a membrane-associated protein required for endocytosis of synaptic vesicles.
Two models have been proposed for endophilin: that it alters lipid composition in order to …