Nuclear factor (NF)-κB has evolved as a latent, inducible family of transcription factors
fundamental in the control of the inflammatory response. The transcription of hundreds of …

ABSTRACT The COMMD Protein Family is highly conserved among multicellular eukaryotic
organisms and many orthologs of human COMMD genes have been found in different …

COMMD1 deficiency results in defective copper homeostasis, but the mechanism for this has
remained elusive. Here we report that COMMD1 is directly linked to early endosomes …

The recycling of membrane proteins from endosomes to the cell surface is vital for cell
signaling and survival. Retriever, a trimeric complex of vacuolar protein-sorting-associated …

Objectives Cuproptosis is a recently discovered form of programmed cell death; however, its
role in ulcerative colitis (UC) remains a void. Methods Three gene expression profiles were …

Copper is an essential transition metal for all eukaryotes. In mammals, intestinal copper
absorption is mediated by the ATP7A copper transporter, whereas copper excretion occurs …

Background The copper metabolism MURR1 domain (COMMD) protein family involved in
tumor development and progression in several types of human cancer, but little is known …

Sustained activation of nuclear factor-κB (NF-κB) in cancer cells has been shown to promote
inflammation, expansion of cancer stem cell (CSC) population, and tumor development. In …

Copper is a trace element indispensable for life, but at the same time it is implicated in
reactive oxygen species formation. Several inherited copper storage diseases are described …

Liver-resident macrophages Kupffer cells (KCs) and infiltrating Ly6C hi monocytes both
contribute to liver tissue regeneration in various pathologies but also to disease progression …