Once considered exclusively the cell's powerhouse, mitochondria are now recognized to
perform multiple essential functions beyond energy production, impacting most areas of cell …

Mammalian oocytes and early cleavage-stage embryos are critically dependent on their~
100,000 mitochondria to develop from ovulation to compacted morula stage. They rely …

Maternally inherited mitochondrial (mt) DNA mutations can cause fatal or severely
debilitating syndromes in children,,, with disease severity dependent on the specific gene …

Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a
broad range of debilitating and fatal diseases. Reproductive technologies designed to …

Since their endosymbiotic origin, mitochondria have lost most of their genes. Although many
selective mechanisms underlying the evolution of mitochondrial genomes have been …

The aim of this review was to provide an evidence-based approach to frequently asked
questions relating to the risk of transmitting a maternally inherited mitochondrial disorder …

The objective of this review is to outline existing artificial mitochondria transfer techniques
and to describe the future steps necessary to develop new therapeutic applications in …

Metabolic diseases, including obesity, diabetes, and nonalcoholic fatty liver disease
(NAFLD), are rising in both incidence and prevalence and remain a major global health and …

Mitochondrial diseases are a group of inherited or acquired metabolic disorders caused by
mitochondrial dysfunction which may affect almost all the organs in the body and present at …

BACKGROUND The use of nuclear transfer (NT) has been proposed as a novel
reproductive treatment to overcome the transmission of maternally-inherited mitochondrial …