Synaptic activity imposes large energy demands that are met by local adenosine
triphosphate (ATP) synthesis through glycolysis and mitochondrial oxidative …

James Parkinson first described the motor symptoms of the disease that took his name over
200 years ago. While our knowledge of many of the changes that occur in this condition has …

Neuronal computation is energetically expensive. Consequently, the brain's limited energy
supply imposes constraints on its information processing capability. Most brain energy is …

Mitochondria have a number of essential roles in neuronal function. Their complex mobility
patterns within neurons are characterized by frequent changes in direction. Mobile …

Mitochondria are present in the pre-and post-synaptic regions, providing the energy
required for the activity of these very specialized neuronal compartments. Biogenesis of …

Neurons, perhaps more than any other cell type, depend on mitochondrial trafficking for their
survival. Recent studies have elucidated a motor/adaptor complex on the mitochondrial …

Intracellular transport is fundamental for cellular function, survival and morphogenesis.
Kinesin superfamily proteins (also known as KIFs) are important molecular motors that …

Vigorous transport of cytoplasmic components along axons over substantial distances is
crucial for the maintenance of neuron structure and function. The transport of mitochondria …

Fast axonal transport (FAT) requires consistent energy over long distances to fuel the
molecular motors that transport vesicles. We demonstrate that glycolysis provides ATP for …

Mitochondria are essential organelles for neuronal growth, survival, and function. Neurons
use specialized mechanisms to drive mitochondria transport and to anchor them in axons …