BACKGROUND: The tripeptide γ-glutamylcysteinylglycine or glutathione (GSH) has
demonstrated protective abilities against the detrimental effects of oxidative stress within the …

Anthelminthics remain the only accessible means in the struggle against helminth parasites,
which cause significant morbidity and mortality in man and farm animals. The treatment of …

Chalcone derivatives were evaluated for their antifilarial activity on Setaria cervi using
glutathione-S-transferase (GST) as a drug target. The compounds 1-(4-benzotriazol-1-yl …

A bio-assay guided fractionation and purification approach was used to examine in vitro
antifilarial activities of the crude methanolic extract of Nyctanthes arbortristis as well as …

Background Filarial nematode parasites cause serious diseases such as elephantiasis and
river blindness in humans, and heartworm infections in dogs. Third stage filarial larvae (L3) …

Present report enumerates the vaccine potential of a glutathione-S-transferase purified from
Setaria cervi against lymphatic filariasis. In jirds (Meriones unguiculatus) vaccination trial, a …

Since glutathione-S-transferase (GST) mediated xenobiotic detoxification is a crucial
mechanism in nematodes survival, we aimed to conduct an in silico analysis of filarial GST …

The glutathione reductase (GR) and thioredoxin reductase (TrxR) are important enzymes of
the redox system that aid parasites to maintain an adequate intracellular redox environment …

Context The anthelminthic effect of Ocimum species (Lamiaceae) has been reported,
however, its anti-filarial effect has not been explored to date. Objective This study evaluates …

Diethylcarbamazine (DEC) is the main drug used against lymphatic filariasis but it is only
microfilaricidal. Hence there is an urgent need for adulticidal drug. Aspirin is known …