JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, arising from
immature lymphocytes that show uncontrolled proliferation and arrested differentiation …
immature lymphocytes that show uncontrolled proliferation and arrested differentiation …
The current genomic and molecular landscape of Philadelphia-like acute lymphoblastic leukemia
P Shiraz, KJ Payne, L Muffly - International Journal of Molecular Sciences, 2020 - mdpi.com
Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk B-cell Acute
Lymphoblastic Leukemia (B-ALL) characterized by a gene expression profile similar to Ph …
Lymphoblastic Leukemia (B-ALL) characterized by a gene expression profile similar to Ph …
Commonly assessed markers in childhood BCP-ALL diagnostic panels and their association with genetic aberrations and outcome prediction
J Kulis, Ł Sędek, Ł Słota, B Perkowski, T Szczepański - Genes, 2022 - mdpi.com
Immunophenotypic characterization of leukemic cells with the use of flow cytometry (FC) is a
fundamental tool in acute lymphoblastic leukemia (ALL) diagnostics. A variety of genetic …
fundamental tool in acute lymphoblastic leukemia (ALL) diagnostics. A variety of genetic …
[HTML][HTML] IKZF1 deletions associate with CRLF2 overexpression leading to a poor prognosis in B-cell precursor acute lymphoblastic leukaemia
ALT Maciel, T da Conceição Barbosa, CB Blunck… - Translational …, 2022 - Elsevier
Abstract Cytokine Receptor-Like Factor 2 (CRLF2) overexpression occurs in 5-15% of B-cell
precursor acute lymphoblastic leukaemia (B-ALL). In∼ 50% of these cases, the mechanisms …
precursor acute lymphoblastic leukaemia (B-ALL). In∼ 50% of these cases, the mechanisms …
BCR/ABL1-like acute lymphoblastic leukemia: from diagnostic approaches to molecularly targeted therapy
A Płotka, K Lewandowski - Acta Haematologica, 2022 - karger.com
Background: BCR/ABL1-like acute lymphoblastic leukemia is a newly recognized high-risk
subtype of ALL, characterized by the presence of genetic alterations activating kinase and …
subtype of ALL, characterized by the presence of genetic alterations activating kinase and …
[HTML][HTML] Prognostic relevance of surface expression of cytokine receptor-like factor 2 in pediatric B-lineage acute lymphoblastic leukemia
Overexpression of cytokine receptor-like factor 2 (CRLF2) resulting from its genomic
rearrangement is the most frequent genetic alteration found in Philadelphia chromosome …
rearrangement is the most frequent genetic alteration found in Philadelphia chromosome …
'Evaluation of adverse prognostic gene alterations & MRD positivity in BCR::ABL1-like B-lineage acute lymphoblastic leukaemia patients, in a resource-constrained …
Background Early detection of BCR:: ABL1-like ALL could impact treatment management
and improve the overall survival/outcome. BCR:: ABL1-like ALL cases are characterised by …
and improve the overall survival/outcome. BCR:: ABL1-like ALL cases are characterised by …
Prognostic significance of CRLF2 overexpression and JAK2 mutation in Egyptian pediatric patients with B-precursor acute lymphoblastic leukemia
Background The prognostic significance of cytokine receptor-like factor 2 (CRLF2)
overexpression in pediatric B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) is …
overexpression in pediatric B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) is …
The Role of the JAK–STAT Pathway in Childhood B-Cell Acute Lymphoblastic Leukemia
KJ Ziętara, K Wróblewska, M Zajączkowska… - International Journal of …, 2024 - mdpi.com
B-cell lymphoblastic leukemia is a hematologic neoplasm that poses a serious health
concern in childhood. Genetic aberrations, such as mutations in the genes IL-7, IL7R, JAK1 …
concern in childhood. Genetic aberrations, such as mutations in the genes IL-7, IL7R, JAK1 …
Hematological characteristics, cytogenetic features, and post-induction measurable residual disease in thymic stromal lymphopoietin receptor (TSLPR) overexpressed …
The overexpression of cytokine receptor-like factor-2 (CRLF2) identified by anti-thymic
stromal lymphopoietin receptor/TSLPR flow cytometry (FCM) has been reported as a …
stromal lymphopoietin receptor/TSLPR flow cytometry (FCM) has been reported as a …