Apical–basal progenitor cell polarity establishes key features of the radial and laminar
architecture of the develo** human cortex. The unique diversity of cortical stem cell …

PCDH19-related epilepsy is a distinct childhood-onset epilepsy syndrome characterized by
brief clusters of febrile and afebrile seizures with onset primarily before the age of three …

Investigation of neural circuit dynamics is crucial for deciphering the functional connections
among regions of the brain and understanding the mechanism of brain dysfunction. Despite …

Precise wiring of neural circuits is essential for brain connectivity and function. During
development, axons respond to diverse cues present in the extracellular matrix or at the …

Cerebral cortex expansion is a hallmark of mammalian brain evolution; yet, how increased
neurogenesis is coordinated with structural and functional development remains largely …

The ability to create three-dimensional (3D) models of brain tissue from patient-derived cells,
would open new possibilities in studying the neuropathology of disorders such as epilepsy …

The challenges in making animal models of complex human epilepsy phenotypes with
varied aetiology highlights the need to develop alternative disease models that can address …

PCDH19 is considered one of the most clinically relevant genes in epilepsy, second only to
SCN1A. To date about 150 mutations have been identified as causative for PCDH19‐female …

PCDH19 Clustering Epilepsy (CE) is an intriguing early-onset seizure, autism and
neurocognitive disorder with unique inheritance. The causative gene, PCDH19, is on the X …

During brain development, neurons need to form the correct connections with one another in
order to give rise to a functional neuronal circuitry. Mistakes during this process, leading to …